DegronMD - Q96B18(DACT3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R148H	TCGA-2W-A8YY	CESC	TCGA	DSGFSGS	DEG_SCF_TRCP1_1	137:143	Mutation rewiring degron network	0.1944
p.R148H	DO223732	CESC	ICGC	DSGFSGS	DEG_SCF_TRCP1_1	137:143	Mutation rewiring degron network	0.1944
p.S144N	TCGA-2W-A8YY	CESC	TCGA	DSGFSGS	DEG_SCF_TRCP1_1	137:143	Mutation rewiring degron network	0.3056
p.S144N	DO223732	CESC	ICGC	DSGFSGS	DEG_SCF_TRCP1_1	137:143	Mutation rewiring degron network	0.3056
p.S138N	TCGA-B5-A1MX	UCEC	TCGA	DSGFSGS	DEG_SCF_TRCP1_1	137:143	Mutation altering degron motif	0.7069
p.S138N	DO41999	UCEC	ICGC	DSGFSGS	DEG_SCF_TRCP1_1	137:143	Mutation altering degron motif	0.7069
p.C135S	TCGA-OR-A5KB	ACC	TCGA	DSGFSGS	DEG_SCF_TRCP1_1	137:143	Mutation rewiring degron network	0.2778
p.S439L	DO225295	BRCA	ICGC	PPKY	ITCH	441:444	Mutation rewiring degron network	0.2778
p.S439L	DO228331	BRCA	ICGC	PPKY	ITCH	441:444	Mutation rewiring degron network	0.2778
p.A434T	DO222425	BTCA	ICGC	PPKY	ITCH	441:444	Mutation rewiring degron network	0.1389
p.P131T	DO229022	LICA	ICGC	DSGFSGS	DEG_SCF_TRCP1_1	137:143	Mutation rewiring degron network	0.1667
p.R148C	SIDM00984	Other Blood Cancers	GDSC	DSGFSGS	DEG_SCF_TRCP1_1	137:143	Mutation rewiring degron network	0.1944
p.R148C	SIDM00534	Colorectal Carcinoma	GDSC	DSGFSGS	DEG_SCF_TRCP1_1	137:143	Mutation rewiring degron network	0.1944
p.R148C	BONNA-12	haematopoietic and lymphoid tissue	COSMIC	DSGFSGS	DEG_SCF_TRCP1_1	137:143	Mutation rewiring degron network	0.1944
p.R148C	HT-115	large intestine	COSMIC	DSGFSGS	DEG_SCF_TRCP1_1	137:143	Mutation rewiring degron network	0.1944
p.Y146N	ACH-001068	Lymphoma	CCLE	DSGFSGS	DEG_SCF_TRCP1_1	137:143	Mutation rewiring degron network	0.25
p.R453Q	ACH-001458	Colon/Colorectal Cancer	CCLE	PPKY	ITCH	441:444	Mutation rewiring degron network	0.0833
p.A436T	ACH-001669	Leukemia	CCLE	PPKY	ITCH	441:444	Mutation rewiring degron network	0.1944

Kaplan plot for DACT3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DACT3

UniProt ID: Q96B18

Entrez ID: 147906

Protein name: Dapper homolog 3 (Antagonist of beta-catenin Dapper homolog 3) (Arginine-rich region 1 protein) (Dapper antagonist of catenin 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DACT3 in