DegronMD

Uniprot ID: Q96B18

Source protein: Dapper homolog 3

Source gene: DACT3

Class: DEG_SCF_TRCP1_1

Location: 137:143

E3 ligase: BTRC

DEGRON score: 0.9458

ASA_SCORE: 69.4

COIL: 0.8601

CONS_SCORE: 0.7253

DSS_SCORE: 0.5739

HELIX: 0.0459

FCONS_SCORE: 1.0485

RIG_SCORE: 0.5877

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R148H	TCGA-2W-A8YY	CESC	TCGA	DSGFSGS	DEG_SCF_TRCP1_1	0.1944
p.R148H	DO223732	CESC	ICGC	DSGFSGS	DEG_SCF_TRCP1_1	0.1944
p.S144N	TCGA-2W-A8YY	CESC	TCGA	DSGFSGS	DEG_SCF_TRCP1_1	0.3056
p.S144N	DO223732	CESC	ICGC	DSGFSGS	DEG_SCF_TRCP1_1	0.3056
p.S138N	TCGA-B5-A1MX	UCEC	TCGA	DSGFSGS	DEG_SCF_TRCP1_1	0.7069
p.S138N	DO41999	UCEC	ICGC	DSGFSGS	DEG_SCF_TRCP1_1	0.7069
p.C135S	TCGA-OR-A5KB	ACC	TCGA	DSGFSGS	DEG_SCF_TRCP1_1	0.2778
p.P131T	DO229022	LICA	ICGC	DSGFSGS	DEG_SCF_TRCP1_1	0.1667
p.R148C	SIDM00984	Other Blood Cancers	GDSC	DSGFSGS	DEG_SCF_TRCP1_1	0.1944
p.R148C	SIDM00534	Colorectal Carcinoma	GDSC	DSGFSGS	DEG_SCF_TRCP1_1	0.1944
p.R148C	BONNA-12	haematopoietic_and_lymphoid_tissue	COSMIC	DSGFSGS	DEG_SCF_TRCP1_1	0.1944
p.R148C	HT-115	large_intestine	COSMIC	DSGFSGS	DEG_SCF_TRCP1_1	0.1944
p.Y146N	ACH-001068	Lymphoma	CCLE	DSGFSGS	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96B18	Dapper homolog 3	DEG_SCF_TRCP1_1	137:143	DSGFSGS	BTRC	0.9458	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons