DegronMD - Q8N6H7(ARFGAP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S364A	TCGA-86-A4P7	LUAD	TCGA	PPKY	ITCH	355:358	Mutation blocking phosphorylation signal	0.6111
p.A352T	TCGA-A5-A0G2	UCEC	TCGA	LDLFDD	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.1944
p.A352T	TCGA-A5-A0G2	UCEC	TCGA	PPKY	ITCH	355:358	Mutation rewiring degron network	0.25
p.P332S	TCGA-AP-A059	UCEC	TCGA	LDLFDD	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.0556
p.N361D	TCGA-B5-A11E	UCEC	TCGA	PPKY	ITCH	355:358	Mutation rewiring degron network	0.25
p.N361D	TCGA-EO-A22R	UCEC	TCGA	PPKY	ITCH	355:358	Mutation rewiring degron network	0.25
p.K357N	TCGA-DK-A6B6	BLCA	TCGA	PPKY	ITCH	355:358	Mutation altering degron motif	0.5806
p.F363L	TCGA-FK-A3SB	THCA	TCGA	PPKY	ITCH	355:358	Mutation rewiring degron network	0.1944
p.F363L	SIDM00660	Colorectal Carcinoma	GDSC	PPKY	ITCH	355:358	Mutation rewiring degron network	0.1944
p.F363L	ACH-000985	Colon/Colorectal Cancer	CCLE	PPKY	ITCH	355:358	Mutation rewiring degron network	0.1944
p.F363L	LS-411N	large intestine	COSMIC	PPKY	ITCH	355:358	Mutation rewiring degron network	0.1944
p.A335V	TCGA-NJ-A4YP	LUAD	TCGA	LDLFDD	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.1389
p.V333A	SIDM02059	Colorectal Carcinoma	GDSC	LDLFDD	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.0833
p.R339L	SIDM00570	Gastric Carcinoma	GDSC	LDLFDD	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.25
p.R339L	SIDM01449	Pancreatic Carcinoma	GDSC	LDLFDD	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.25
p.R339L	SIDM01464	Pancreatic Carcinoma	GDSC	LDLFDD	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.25
p.R339L	NUGC-4	stomach	COSMIC	LDLFDD	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.25
p.R339H	SIDM00846	Cervical Carcinoma	GDSC	LDLFDD	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.25
p.R339H	SIDM00530	Esophageal Carcinoma	GDSC	LDLFDD	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.25
p.R339H	SIDM00807	Bladder Carcinoma	GDSC	LDLFDD	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.25
p.R339H	SIDM00863	Burkitt's Lymphoma	GDSC	LDLFDD	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.25
p.R339H	SIDM01409	Bladder Carcinoma	GDSC	LDLFDD	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.25
p.S338C	SIDM00619	Thyroid Gland Carcinoma	GDSC	LDLFDD	LIG_APCC_ABBA_1	342:347	Mutation blocking phosphorylation signal	0.6667
p.S338C	ACH-002397	Thyroid Cancer	CCLE	LDLFDD	LIG_APCC_ABBA_1	342:347	Mutation blocking phosphorylation signal	0.6667
p.S338C	KMH-2	thyroid	COSMIC	LDLFDD	LIG_APCC_ABBA_1	342:347	Mutation blocking phosphorylation signal	0.6667
p.D360V	SIDM01561	Melanoma	GDSC	PPKY	ITCH	355:358	Mutation rewiring degron network	0.2778
p.D360V	ACH-000799	Skin Cancer	CCLE	PPKY	ITCH	355:358	Mutation rewiring degron network	0.2778
p.F335L	LS-411N	large intestine	COSMIC	LDLFDD	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.1389
p.P349A	KS-1	central nervous system	COSMIC	LDLFDD	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.2778
p.P349A	KS-1	central nervous system	COSMIC	PPKY	ITCH	355:358	Mutation rewiring degron network	0.1667
p.K359N	GP5d	large intestine	COSMIC	PPKY	ITCH	355:358	Mutation blocking ubiquitination signal	0.75
p.S367N	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PPKY	ITCH	355:358	Mutation rewiring degron network	0.0833
p.S343F	LU-99A	lung	COSMIC	LDLFDD	LIG_APCC_ABBA_1	342:347	Mutation altering degron motif	0.7982
p.A351V	MCC26	skin	COSMIC	LDLFDD	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.2222
p.A351V	MCC26	skin	COSMIC	PPKY	ITCH	355:358	Mutation rewiring degron network	0.2222

Kaplan plot for ARFGAP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARFGAP2

UniProt ID: Q8N6H7

Entrez ID: 84364

Protein name: ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARFGAP2 in