DegronMD

Uniprot ID: Q8N6H7

Source protein: ADP-ribosylation factor GTPase-activating protein 2

Source gene: ARFGAP2

Class: LIG_APCC_ABBA_1

Location: 342:347

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9232

ASA_SCORE: 66.5833

COIL: 0.6205

CONS_SCORE: 0.2215

DSS_SCORE: 0.4356

HELIX: 0.2935

FCONS_SCORE: 0.7705

RIG_SCORE: 0.7838

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A352T	TCGA-A5-A0G2	UCEC	TCGA	LDLFDD	LIG_APCC_ABBA_1	0.1944
p.P332S	TCGA-AP-A059	UCEC	TCGA	LDLFDD	LIG_APCC_ABBA_1	0.0556
p.A335V	TCGA-NJ-A4YP	LUAD	TCGA	LDLFDD	LIG_APCC_ABBA_1	0.1389
p.V333A	SIDM02059	Colorectal Carcinoma	GDSC	LDLFDD	LIG_APCC_ABBA_1	0.0833
p.R339L	SIDM00570	Gastric Carcinoma	GDSC	LDLFDD	LIG_APCC_ABBA_1	0.25
p.R339L	SIDM01449	Pancreatic Carcinoma	GDSC	LDLFDD	LIG_APCC_ABBA_1	0.25
p.R339L	SIDM01464	Pancreatic Carcinoma	GDSC	LDLFDD	LIG_APCC_ABBA_1	0.25
p.R339L	NUGC-4	stomach	COSMIC	LDLFDD	LIG_APCC_ABBA_1	0.25
p.R339H	SIDM00846	Cervical Carcinoma	GDSC	LDLFDD	LIG_APCC_ABBA_1	0.25
p.R339H	SIDM00530	Esophageal Carcinoma	GDSC	LDLFDD	LIG_APCC_ABBA_1	0.25
p.R339H	SIDM00807	Bladder Carcinoma	GDSC	LDLFDD	LIG_APCC_ABBA_1	0.25
p.R339H	SIDM00863	Burkitt's Lymphoma	GDSC	LDLFDD	LIG_APCC_ABBA_1	0.25
p.R339H	SIDM01409	Bladder Carcinoma	GDSC	LDLFDD	LIG_APCC_ABBA_1	0.25
p.S338C	SIDM00619	Thyroid Gland Carcinoma	GDSC	LDLFDD	LIG_APCC_ABBA_1	0.6667
p.S338C	ACH-002397	Thyroid Cancer	CCLE	LDLFDD	LIG_APCC_ABBA_1	0.6667
p.S338C	KMH-2	thyroid	COSMIC	LDLFDD	LIG_APCC_ABBA_1	0.6667
p.F335L	LS-411N	large_intestine	COSMIC	LDLFDD	LIG_APCC_ABBA_1	0.1389
p.P349A	KS-1	central_nervous_system	COSMIC	LDLFDD	LIG_APCC_ABBA_1	0.2778
p.S343F	LU-99A	lung	COSMIC	LDLFDD	LIG_APCC_ABBA_1	0.7982
p.A351V	MCC26	skin	COSMIC	LDLFDD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N6H7	ADP-ribosylation factor GTPase-activating protein 2	LIG_APCC_ABBA_1	342:347	LDLFDD	APC,CDC20,FZR1	0.9232	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons