DegronMD - Q06190(PPP2R3A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P358S	TCGA-77-8143	LUSC	TCGA	DSGRFQT	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.1111
p.P358S	DO27247	LUSC	ICGC	DSGRFQT	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.1111
p.Q349E	TCGA-AC-A6IW	BRCA	TCGA	DSGRFQT	DEG_SCF_TRCP1_1	344:350	Mutation altering degron motif	0.5633
p.Q349E	DO50028	BRCA	ICGC	DSGRFQT	DEG_SCF_TRCP1_1	344:350	Mutation altering degron motif	0.5633
p.D356G	TCGA-CA-6717	COAD	TCGA	DSGRFQT	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.1667
p.D356G	DO8264	COAD	ICGC	DSGRFQT	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.1667
p.S360Y	TCGA-CA-6717	COAD	TCGA	DSGRFQT	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.0556
p.S360Y	DO8264	COAD	ICGC	DSGRFQT	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.0556
p.E335K	TCGA-DK-A2I2	BLCA	TCGA	DSGRFQT	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.0833
p.E335K	TCGA-DK-A2I2	BLCA	TCGA	PPKY	ITCH	331:334	Mutation rewiring degron network	0.3056
p.E335K	DO708	BLCA	ICGC	DSGRFQT	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.0833
p.E335K	DO708	BLCA	ICGC	PPKY	ITCH	331:334	Mutation rewiring degron network	0.3056
p.G327A	DO230322	COCA	ICGC	PPKY	ITCH	331:334	Mutation rewiring degron network	0.2222
p.I345N	DO234193	ESAD	ICGC	DSGRFQT	DEG_SCF_TRCP1_1	344:350	Mutation altering degron motif	0.728
p.G327C	DO229025	LICA	ICGC	PPKY	ITCH	331:334	Mutation rewiring degron network	0.2222
p.A338S	DO229045	LICA	ICGC	DSGRFQT	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.1667
p.A338S	DO229045	LICA	ICGC	PPKY	ITCH	331:334	Mutation rewiring degron network	0.2222
p.Y337N	DO50966	LICA	ICGC	DSGRFQT	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.1389
p.Y337N	DO50966	LICA	ICGC	PPKY	ITCH	331:334	Mutation rewiring degron network	0.25
p.A342V	SIDM00482	Chronic Myelogenous Leukemia	GDSC	DSGRFQT	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.2778
p.A342V	SIDM00482	Chronic Myelogenous Leukemia	GDSC	PPKY	ITCH	331:334	Mutation rewiring degron network	0.1111
p.A342V	ACH-002302	Leukemia	CCLE	DSGRFQT	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.2778
p.A342V	ACH-002302	Leukemia	CCLE	PPKY	ITCH	331:334	Mutation rewiring degron network	0.1111
p.A342V	RPMI-8866	haematopoietic and lymphoid tissue	COSMIC	DSGRFQT	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.2778
p.A342V	RPMI-8866	haematopoietic and lymphoid tissue	COSMIC	PPKY	ITCH	331:334	Mutation rewiring degron network	0.1111
p.V337D	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	DSGRFQT	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.1389
p.V337D	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	PPKY	ITCH	331:334	Mutation rewiring degron network	0.25
p.V337D	ACH-000837	Lung Cancer	CCLE	DSGRFQT	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.1389
p.V337D	ACH-000837	Lung Cancer	CCLE	PPKY	ITCH	331:334	Mutation rewiring degron network	0.25
p.V337D	NCI-H322M	lung	COSMIC	DSGRFQT	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.1389
p.V337D	NCI-H322M	lung	COSMIC	PPKY	ITCH	331:334	Mutation rewiring degron network	0.25
p.T328R	HCT-15	large intestine	COSMIC	PPKY	ITCH	331:334	Mutation rewiring degron network	0.25
p.P353A	M14	skin	COSMIC	DSGRFQT	DEG_SCF_TRCP1_1	344:350	Mutation rewiring degron network	0.25

Kaplan plot for PPP2R3A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPP2R3A

UniProt ID: Q06190

Entrez ID: 5523

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPP2R3A in