DegronMD

Uniprot ID: Q06190

Source protein: Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

Source gene: PPP2R3A

Class: DEG_SCF_TRCP1_1

Location: 344:350

E3 ligase: BTRC

DEGRON score: 0.9604

ASA_SCORE: 90.3714

COIL: 0.793

CONS_SCORE: 0.2422

DSS_SCORE: 0.5476

HELIX: 0.1507

FCONS_SCORE: 0.898

RIG_SCORE: 0.722

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P358S	TCGA-77-8143	LUSC	TCGA	DSGRFQT	DEG_SCF_TRCP1_1	0.1111
p.P358S	DO27247	LUSC	ICGC	DSGRFQT	DEG_SCF_TRCP1_1	0.1111
p.Q349E	TCGA-AC-A6IW	BRCA	TCGA	DSGRFQT	DEG_SCF_TRCP1_1	0.5633
p.Q349E	DO50028	BRCA	ICGC	DSGRFQT	DEG_SCF_TRCP1_1	0.5633
p.D356G	TCGA-CA-6717	COAD	TCGA	DSGRFQT	DEG_SCF_TRCP1_1	0.1667
p.D356G	DO8264	COAD	ICGC	DSGRFQT	DEG_SCF_TRCP1_1	0.1667
p.S360Y	TCGA-CA-6717	COAD	TCGA	DSGRFQT	DEG_SCF_TRCP1_1	0.0556
p.S360Y	DO8264	COAD	ICGC	DSGRFQT	DEG_SCF_TRCP1_1	0.0556
p.E335K	TCGA-DK-A2I2	BLCA	TCGA	DSGRFQT	DEG_SCF_TRCP1_1	0.0833
p.E335K	DO708	BLCA	ICGC	DSGRFQT	DEG_SCF_TRCP1_1	0.0833
p.I345N	DO234193	ESAD	ICGC	DSGRFQT	DEG_SCF_TRCP1_1	0.728
p.A338S	DO229045	LICA	ICGC	DSGRFQT	DEG_SCF_TRCP1_1	0.1667
p.Y337N	DO50966	LICA	ICGC	DSGRFQT	DEG_SCF_TRCP1_1	0.1389
p.A342V	SIDM00482	Chronic Myelogenous Leukemia	GDSC	DSGRFQT	DEG_SCF_TRCP1_1	0.2778
p.A342V	ACH-002302	Leukemia	CCLE	DSGRFQT	DEG_SCF_TRCP1_1	0.2778
p.A342V	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	DSGRFQT	DEG_SCF_TRCP1_1	0.2778
p.V337D	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	DSGRFQT	DEG_SCF_TRCP1_1	0.1389
p.V337D	ACH-000837	Lung Cancer	CCLE	DSGRFQT	DEG_SCF_TRCP1_1	0.1389
p.V337D	NCI-H322M	lung	COSMIC	DSGRFQT	DEG_SCF_TRCP1_1	0.1389
p.P353A	M14	skin	COSMIC	DSGRFQT	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q06190	Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha	DEG_SCF_TRCP1_1	344:350	DSGRFQT	BTRC	0.9604	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons