DegronMD

Uniprot ID: Q8NDZ0

Source protein: BEN domain-containing protein 2

Source gene: BEND2

Class: DEG_SCF_TRCP1_1

Location: 460:466

E3 ligase: BTRC

DEGRON score: 0.8049

ASA_SCORE: 81.0143

COIL: 0.9084

CONS_SCORE: 0.3705

DSS_SCORE: 0.4847

HELIX: 0.0671

FCONS_SCORE: 0.9794

RIG_SCORE: 0.5925

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S461I	TCGA-55-A494	LUAD	TCGA	DSGQDSS	DEG_SCF_TRCP1_1	0.7341
p.S461I	DO23794	LUAD	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	0.7341
p.M451I	TCGA-A5-A0G2	UCEC	TCGA	DSGQDSS	DEG_SCF_TRCP1_1	0.0833
p.M451I	TCGA-AJ-A3EL	UCEC	TCGA	DSGQDSS	DEG_SCF_TRCP1_1	0.0833
p.M451I	DO41542	UCEC	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	0.0833
p.M451I	DO41235	UCEC	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	0.0833
p.R453H	TCGA-AA-3984	COAD	TCGA	DSGQDSS	DEG_SCF_TRCP1_1	0.1389
p.R453H	DO9002	COAD	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	0.1389
p.R453H	SIDM00534	Colorectal Carcinoma	GDSC	DSGQDSS	DEG_SCF_TRCP1_1	0.1389
p.R453H	ACH-000986	Colon/Colorectal Cancer	CCLE	DSGQDSS	DEG_SCF_TRCP1_1	0.1389
p.R453H	HT-115	large_intestine	COSMIC	DSGQDSS	DEG_SCF_TRCP1_1	0.1389
p.R453C	TCGA-AC-A23H	BRCA	TCGA	DSGQDSS	DEG_SCF_TRCP1_1	0.1389
p.R453C	TCGA-AJ-A5DW	UCEC	TCGA	DSGQDSS	DEG_SCF_TRCP1_1	0.1389
p.R453C	DO2401	BRCA	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	0.1389
p.R453C	DO229459	SKCA	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	0.1389
p.R453C	DO50075	UCEC	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	0.1389
p.S469Y	TCGA-AX-A2HC	UCEC	TCGA	DSGQDSS	DEG_SCF_TRCP1_1	0.25
p.S469Y	DO41572	UCEC	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	0.25
p.S469C	TCGA-BT-A42E	BLCA	TCGA	DSGQDSS	DEG_SCF_TRCP1_1	0.25
p.S469C	DO44030	BLCA	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	0.25
p.L457S	DO10172	COAD	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	0.25
p.R453S	DO229038	LICA	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	0.1389
p.G462D	DO228138	PBCA	ICGC	DSGQDSS	DEG_SCF_TRCP1_1	0.7198
p.A456V	SNU-1040	large_intestine	COSMIC	DSGQDSS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NDZ0	BEN domain-containing protein 2	DEG_SCF_TRCP1_1	460:466	DSGQDSS	BTRC	0.8049	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons