DegronMD

Uniprot ID: P20810

Source protein: Calpastatin

Source gene: CAST

Class: DEG_SPOP_SBC_1

Location: 547:551

E3 ligase: SPOP

DEGRON score: 0.9976

ASA_SCORE: 81.2

COIL: 0.9004

CONS_SCORE: 0.6366

DSS_SCORE: 0.679

HELIX: 0.0524

FCONS_SCORE: 1.1668

RIG_SCORE: 0.6398

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E559K	TCGA-78-7539	LUAD	TCGA	PASTT	DEG_SPOP_SBC_1	0.1111
p.E559K	DO26210	LUAD	ICGC	PASTT	DEG_SPOP_SBC_1	0.1111
p.A556V	TCGA-AP-A059	UCEC	TCGA	PASTT	DEG_SPOP_SBC_1	0.1944
p.A556V	DO41361	UCEC	ICGC	PASTT	DEG_SPOP_SBC_1	0.1944
p.F561L	TCGA-B5-A11N	UCEC	TCGA	PASTT	DEG_SPOP_SBC_1	0.5
p.F561L	DO41458	UCEC	ICGC	PASTT	DEG_SPOP_SBC_1	0.5
p.L553I	TCGA-VQ-A8P2	STAD	TCGA	PASTT	DEG_SPOP_SBC_1	0.2778
p.L553I	DO51761	STAD	ICGC	PASTT	DEG_SPOP_SBC_1	0.2778
p.D549H	DO44242	BRCA	ICGC	PASTT	DEG_SPOP_SBC_1	0.7688
p.A556S	DO229032	LICA	ICGC	PASTT	DEG_SPOP_SBC_1	0.1944
p.A556S	HMV-II	skin	COSMIC	PASTT	DEG_SPOP_SBC_1	0.1944
p.M538V	DO229156	NKTL	ICGC	PASTT	DEG_SPOP_SBC_1	0.0833
p.P558R	HCC-366	lung	COSMIC	PASTT	DEG_SPOP_SBC_1	0.1389
p.R558C	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	PASTT	DEG_SPOP_SBC_1	0.1389
p.A560S	HMV-II	skin	COSMIC	PASTT	DEG_SPOP_SBC_1	0.5278
p.K542N	FTC-133	thyroid	COSMIC	PASTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	983:987	PASTT	SPOP	0.9313	More...
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	988:992	PASTT	SPOP	0.889	More...
P11161	E3 SUMO-protein ligase EGR2	DEG_SPOP_SBC_1	127:131	PASTT	SPOP	0.9571	More...
P20810	Calpastatin	DEG_SPOP_SBC_1	547:551	PASTT	SPOP	0.9976	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	93:97	PASTT	SPOP	0.9667	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2297:2301	PASTT	SPOP	0.6997	More...
P98171	Rho GTPase-activating protein 4	DEG_SPOP_SBC_1	894:898	PASTT	SPOP	0.9571	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1511:1515	PASTT	SPOP	0.6572	More...
Q08999	Retinoblastoma-like protein 2	DEG_SPOP_SBC_1	674:678	PASTT	SPOP	0.9981	More...
Q5THR3	EF-hand calcium-binding domain-containing protein 6	DEG_SPOP_SBC_1	1295:1299	PASTT	SPOP	0.9774	More...
Q6BAA4	Fc receptor-like B	DEG_SPOP_SBC_1	294:298	PASTT	SPOP	0.9844	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	358:362	PASTT	SPOP	0.974	More...
Q99607	ETS-related transcription factor Elf-4	DEG_SPOP_SBC_1	433:437	PASTT	SPOP	0.7975	More...
Q9BR76	Coronin-1B	DEG_SPOP_SBC_1	429:433	PASTT	SPOP	0.9688	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1644:1648	PASTT	SPOP	0.9635	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4925:4929	PASTT	SPOP	0.9738	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4981:4985	PASTT	SPOP	0.7062	More...
Q9Y692	Glucocorticoid modulatory element-binding protein 1	DEG_SPOP_SBC_1	385:389	PASTT	SPOP	0.947	More...
A6NMD0	Interferon-induced transmembrane protein 10	DEG_SPOP_SBC_1	42:46	PASTT	SPOP	0.9896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PASTT

Degron related mutations and impact score

Drug responses associated with CAST mutations

All proteins holding degron of PASTT