DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SPOP_SBC_1

Location: 358:362

E3 ligase: SPOP

DEGRON score: 0.974

ASA_SCORE: 90.1

COIL: 0.9614

CONS_SCORE: 0.3255

DSS_SCORE: 0.8213

HELIX: 0.0142

FCONS_SCORE: 1.0133

RIG_SCORE: 0.5529

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P363H	TCGA-33-4532	LUSC	TCGA	PASTT	DEG_SPOP_SBC_1	0.3056
p.P363H	DO26626	LUSC	ICGC	PASTT	DEG_SPOP_SBC_1	0.3056
p.E349G	TCGA-B0-4823	KIRC	TCGA	PASTT	DEG_SPOP_SBC_1	0.0833
p.E349G	DO18492	KIRC	ICGC	PASTT	DEG_SPOP_SBC_1	0.0833
p.S360F	TCGA-E2-A2P6	BRCA	TCGA	PASTT	DEG_SPOP_SBC_1	0.7982
p.S360F	DO4173	BRCA	ICGC	PASTT	DEG_SPOP_SBC_1	0.7982
p.E349K	TCGA-EE-A29D	SKCM	TCGA	PASTT	DEG_SPOP_SBC_1	0.0833
p.E349K	DO38123	SKCM	ICGC	PASTT	DEG_SPOP_SBC_1	0.0833
p.T361I	SIDM01173	Rhabdomyosarcoma	GDSC	PASTT	DEG_SPOP_SBC_1	0.7078
p.E357K	SIDM01443	Gastric Carcinoma	GDSC	PASTT	DEG_SPOP_SBC_1	0.3056
p.E357K	ACH-000344	Gastric Cancer	CCLE	PASTT	DEG_SPOP_SBC_1	0.3056
p.P355R	TE-6	oesophagus	COSMIC	PASTT	DEG_SPOP_SBC_1	0.25
p.A372S	D-542MG	central_nervous_system	COSMIC	PASTT	DEG_SPOP_SBC_1	0.1667
p.A370S	D-542MG	central_nervous_system	COSMIC	PASTT	DEG_SPOP_SBC_1	0.1111
p.K349E	SK-GT-2	stomach	COSMIC	PASTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	983:987	PASTT	SPOP	0.9313	More...
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	988:992	PASTT	SPOP	0.889	More...
P11161	E3 SUMO-protein ligase EGR2	DEG_SPOP_SBC_1	127:131	PASTT	SPOP	0.9571	More...
P20810	Calpastatin	DEG_SPOP_SBC_1	547:551	PASTT	SPOP	0.9976	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	93:97	PASTT	SPOP	0.9667	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2297:2301	PASTT	SPOP	0.6997	More...
P98171	Rho GTPase-activating protein 4	DEG_SPOP_SBC_1	894:898	PASTT	SPOP	0.9571	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1511:1515	PASTT	SPOP	0.6572	More...
Q08999	Retinoblastoma-like protein 2	DEG_SPOP_SBC_1	674:678	PASTT	SPOP	0.9981	More...
Q5THR3	EF-hand calcium-binding domain-containing protein 6	DEG_SPOP_SBC_1	1295:1299	PASTT	SPOP	0.9774	More...
Q6BAA4	Fc receptor-like B	DEG_SPOP_SBC_1	294:298	PASTT	SPOP	0.9844	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	358:362	PASTT	SPOP	0.974	More...
Q99607	ETS-related transcription factor Elf-4	DEG_SPOP_SBC_1	433:437	PASTT	SPOP	0.7975	More...
Q9BR76	Coronin-1B	DEG_SPOP_SBC_1	429:433	PASTT	SPOP	0.9688	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1644:1648	PASTT	SPOP	0.9635	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4925:4929	PASTT	SPOP	0.9738	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4981:4985	PASTT	SPOP	0.7062	More...
Q9Y692	Glucocorticoid modulatory element-binding protein 1	DEG_SPOP_SBC_1	385:389	PASTT	SPOP	0.947	More...
A6NMD0	Interferon-induced transmembrane protein 10	DEG_SPOP_SBC_1	42:46	PASTT	SPOP	0.9896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PASTT

Degron related mutations and impact score

Drug responses associated with PRG4 mutations

All proteins holding degron of PASTT