DegronMD - Q08999(RBL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R428C	TCGA-13-1477	OV	TCGA	PCVTPVST	DEG_SCF_FBW7_1	414:421	Mutation rewiring degron network	0.1389
p.R428C	TCGA-KO-8408	KICH	TCGA	PCVTPVST	DEG_SCF_FBW7_1	414:421	Mutation rewiring degron network	0.1389
p.H430Y	TCGA-85-A512	LUSC	TCGA	PCVTPVST	DEG_SCF_FBW7_1	414:421	Mutation rewiring degron network	0.0833
p.L429I	TCGA-A5-A0G2	UCEC	TCGA	PCVTPVST	DEG_SCF_FBW7_1	414:421	Mutation rewiring degron network	0.1111
p.Y408C	TCGA-AA-3715	COAD	TCGA	IKENS	DEG_APCC_KENBOX_2	409:413	Mutation rewiring degron network	0.3056
p.Y408C	TCGA-AA-3715	COAD	TCGA	PCVTPVST	DEG_SCF_FBW7_1	414:421	Mutation rewiring degron network	0.1667
p.P674T	TCGA-AX-A06F	UCEC	TCGA	PASTT	DEG_SPOP_SBC_1	674:678	Mutation altering degron motif	0.7031
p.P674T	TCGA-AX-A06F	UCEC	TCGA	DRYSSPP	CBL_PTK	668:674	Mutation altering degron motif	0.7031
p.P674T	DO41752	UCEC	ICGC	PASTT	DEG_SPOP_SBC_1	674:678	Mutation altering degron motif	0.7031
p.P674T	DO41752	UCEC	ICGC	DRYSSPP	CBL_PTK	668:674	Mutation altering degron motif	0.7031
p.P663A	TCGA-BA-4076	HNSC	TCGA	DRYSSPP	CBL_PTK	668:674	Mutation rewiring degron network	0.1944
p.P663A	DO14502	HNSC	ICGC	DRYSSPP	CBL_PTK	668:674	Mutation rewiring degron network	0.1944
p.S420F	TCGA-DK-AA6S	BLCA	TCGA	PCVTPVST	DEG_SCF_FBW7_1	414:421	Mutation altering degron motif	0.6871
p.R428S	TCGA-KQ-A41N	BLCA	TCGA	PCVTPVST	DEG_SCF_FBW7_1	414:421	Mutation rewiring degron network	0.1389
p.Y667C	DO222794	COCA	ICGC	PASTT	DEG_SPOP_SBC_1	674:678	Mutation blocking phosphorylation signal	0.5833
p.Y667C	DO222794	COCA	ICGC	DRYSSPP	CBL_PTK	668:674	Mutation blocking phosphorylation signal	0.75
p.S672F	DO234225	ESAD	ICGC	DRYSSPP	CBL_PTK	668:674	Mutation altering degron motif	0.7982
p.C419G	DO234365	ESAD	ICGC	PCVTPVST	DEG_SCF_FBW7_1	414:421	Mutation altering degron motif	0.76
p.E405D	DO228948	LICA	ICGC	IKENS	DEG_APCC_KENBOX_2	409:413	Mutation rewiring degron network	0.2222
p.E405D	DO228948	LICA	ICGC	PCVTPVST	DEG_SCF_FBW7_1	414:421	Mutation rewiring degron network	0.0833
p.E405D	DO229045	LICA	ICGC	IKENS	DEG_APCC_KENBOX_2	409:413	Mutation rewiring degron network	0.2222
p.E405D	DO229045	LICA	ICGC	PCVTPVST	DEG_SCF_FBW7_1	414:421	Mutation rewiring degron network	0.0833
p.R425H	DO228972	LICA	ICGC	PCVTPVST	DEG_SCF_FBW7_1	414:421	Mutation rewiring degron network	0.2222
p.C403F	DO229028	LICA	ICGC	IKENS	DEG_APCC_KENBOX_2	409:413	Mutation rewiring degron network	0.1667
p.R669S	DO229035	LICA	ICGC	DRYSSPP	CBL_PTK	668:674	Mutation altering degron motif	0.6316
p.R669S	DO229038	LICA	ICGC	DRYSSPP	CBL_PTK	668:674	Mutation altering degron motif	0.6316
p.R425C	DO231110	LUSC	ICGC	PCVTPVST	DEG_SCF_FBW7_1	414:421	Mutation rewiring degron network	0.2222
p.V400A	DO42023	UCEC	ICGC	IKENS	DEG_APCC_KENBOX_2	409:413	Mutation rewiring degron network	0.0833
p.R681W	SIDM02059	Colorectal Carcinoma	GDSC	PASTT	DEG_SPOP_SBC_1	674:678	Mutation rewiring degron network	0.25
p.R681W	SIDM02059	Colorectal Carcinoma	GDSC	DRYSSPP	CBL_PTK	668:674	Mutation rewiring degron network	0.1389
p.T423M	SIDM00220	Ovarian Carcinoma	GDSC	IKENS	DEG_APCC_KENBOX_2	409:413	Mutation rewiring degron network	0.0556
p.T423M	SIDM00220	Ovarian Carcinoma	GDSC	PCVTPVST	DEG_SCF_FBW7_1	414:421	Mutation rewiring degron network	0.2778
p.T423M	ACH-000962	Ovarian Cancer	CCLE	IKENS	DEG_APCC_KENBOX_2	409:413	Mutation rewiring degron network	0.0556
p.T423M	ACH-000962	Ovarian Cancer	CCLE	PCVTPVST	DEG_SCF_FBW7_1	414:421	Mutation rewiring degron network	0.2778
p.T423M	ACH-001145	Ovarian Cancer	CCLE	IKENS	DEG_APCC_KENBOX_2	409:413	Mutation rewiring degron network	0.0556
p.T423M	ACH-001145	Ovarian Cancer	CCLE	PCVTPVST	DEG_SCF_FBW7_1	414:421	Mutation rewiring degron network	0.2778
p.T423M	OC-314	ovary	COSMIC	IKENS	DEG_APCC_KENBOX_2	409:413	Mutation rewiring degron network	0.0556
p.T423M	OC-314	ovary	COSMIC	PCVTPVST	DEG_SCF_FBW7_1	414:421	Mutation rewiring degron network	0.2778
p.T665A	ACH-001610	Brain Cancer	CCLE	PASTT	DEG_SPOP_SBC_1	674:678	Mutation blocking phosphorylation signal	0.5278
p.T665A	ACH-001610	Brain Cancer	CCLE	DRYSSPP	CBL_PTK	668:674	Mutation blocking phosphorylation signal	0.6944

Kaplan plot for RBL2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBL2

UniProt ID: Q08999

Entrez ID: 5934

Protein name: Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBL2 in