DegronMD

Uniprot ID: Q08999

Source protein: Retinoblastoma-like protein 2

Source gene: RBL2

Class: DEG_SCF_FBW7_1

Location: 414:421

E3 ligase: FBXW7

DEGRON score: 0.9994

ASA_SCORE: 70.5375

COIL: 0.8454

CONS_SCORE: 0.4674

DSS_SCORE: 0.3964

HELIX: 0.0745

FCONS_SCORE: 1.1184

RIG_SCORE: 0.7372

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R428C	TCGA-13-1477	OV	TCGA	PCVTPVST	DEG_SCF_FBW7_1	0.1389
p.R428C	TCGA-KO-8408	KICH	TCGA	PCVTPVST	DEG_SCF_FBW7_1	0.1389
p.H430Y	TCGA-85-A512	LUSC	TCGA	PCVTPVST	DEG_SCF_FBW7_1	0.0833
p.L429I	TCGA-A5-A0G2	UCEC	TCGA	PCVTPVST	DEG_SCF_FBW7_1	0.1111
p.Y408C	TCGA-AA-3715	COAD	TCGA	PCVTPVST	DEG_SCF_FBW7_1	0.1667
p.S420F	TCGA-DK-AA6S	BLCA	TCGA	PCVTPVST	DEG_SCF_FBW7_1	0.6871
p.R428S	TCGA-KQ-A41N	BLCA	TCGA	PCVTPVST	DEG_SCF_FBW7_1	0.1389
p.C419G	DO234365	ESAD	ICGC	PCVTPVST	DEG_SCF_FBW7_1	0.76
p.E405D	DO228948	LICA	ICGC	PCVTPVST	DEG_SCF_FBW7_1	0.0833
p.E405D	DO229045	LICA	ICGC	PCVTPVST	DEG_SCF_FBW7_1	0.0833
p.R425H	DO228972	LICA	ICGC	PCVTPVST	DEG_SCF_FBW7_1	0.2222
p.R425C	DO231110	LUSC	ICGC	PCVTPVST	DEG_SCF_FBW7_1	0.2222
p.T423M	SIDM00220	Ovarian Carcinoma	GDSC	PCVTPVST	DEG_SCF_FBW7_1	0.2778
p.T423M	ACH-000962	Ovarian Cancer	CCLE	PCVTPVST	DEG_SCF_FBW7_1	0.2778
p.T423M	ACH-001145	Ovarian Cancer	CCLE	PCVTPVST	DEG_SCF_FBW7_1	0.2778
p.T423M	OC-314	ovary	COSMIC	PCVTPVST	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08999	Retinoblastoma-like protein 2	DEG_SCF_FBW7_1	414:421	PCVTPVST	FBXW7	0.9994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons