DegronMD

Uniprot ID: Q08999

Source protein: Retinoblastoma-like protein 2

Source gene: RBL2

Class: DEG_APCC_KENBOX_2

Location: 409:413

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9662

ASA_SCORE: 100.38

COIL: 0.847

CONS_SCORE: 0.2926

DSS_SCORE: 0.3362

HELIX: 0.0878

FCONS_SCORE: 0.6728

RIG_SCORE: 0.7635

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y408C	TCGA-AA-3715	COAD	TCGA	IKENS	DEG_APCC_KENBOX_2	0.3056
p.E405D	DO228948	LICA	ICGC	IKENS	DEG_APCC_KENBOX_2	0.2222
p.E405D	DO229045	LICA	ICGC	IKENS	DEG_APCC_KENBOX_2	0.2222
p.C403F	DO229028	LICA	ICGC	IKENS	DEG_APCC_KENBOX_2	0.1667
p.V400A	DO42023	UCEC	ICGC	IKENS	DEG_APCC_KENBOX_2	0.0833
p.T423M	SIDM00220	Ovarian Carcinoma	GDSC	IKENS	DEG_APCC_KENBOX_2	0.0556
p.T423M	ACH-000962	Ovarian Cancer	CCLE	IKENS	DEG_APCC_KENBOX_2	0.0556
p.T423M	ACH-001145	Ovarian Cancer	CCLE	IKENS	DEG_APCC_KENBOX_2	0.0556
p.T423M	OC-314	ovary	COSMIC	IKENS	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08999	Retinoblastoma-like protein 2	DEG_APCC_KENBOX_2	409:413	IKENS	APC,CDC20,FZR1	0.9662	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons