DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
DRYSSPP
Uniprot ID:
Q08999
Source protein:
Retinoblastoma-like protein 2
Source gene:
RBL2
Class:
CBL_PTK
Location:
668:674
E3 ligase:
CBL
DEGRON score:
0.9996
ASA_SCORE:
76.1857
COIL:
0.8416
CONS_SCORE:
0.3972
DSS_SCORE:
0.6198
HELIX:
0.09
FCONS_SCORE:
1.3525
RIG_SCORE:
0.696
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P674T
TCGA-AX-A06F
UCEC
TCGA
DRYSSPP
CBL_PTK
0.7031
p.P674T
DO41752
UCEC
ICGC
DRYSSPP
CBL_PTK
0.7031
p.P663A
TCGA-BA-4076
HNSC
TCGA
DRYSSPP
CBL_PTK
0.1944
p.P663A
DO14502
HNSC
ICGC
DRYSSPP
CBL_PTK
0.1944
p.Y667C
DO222794
COCA
ICGC
DRYSSPP
CBL_PTK
0.75
p.S672F
DO234225
ESAD
ICGC
DRYSSPP
CBL_PTK
0.7982
p.R669S
DO229035
LICA
ICGC
DRYSSPP
CBL_PTK
0.6316
p.R669S
DO229038
LICA
ICGC
DRYSSPP
CBL_PTK
0.6316
p.R681W
SIDM02059
Colorectal Carcinoma
GDSC
DRYSSPP
CBL_PTK
0.1389
p.T665A
ACH-001610
Brain Cancer
CCLE
DRYSSPP
CBL_PTK
0.6944
Drug responses associated with RBL2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DRYSSPP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q08999
Retinoblastoma-like protein 2
CBL_PTK
668:674
DRYSSPP
CBL
0.9996
More...
