DegronMD

Uniprot ID: P98171

Source protein: Rho GTPase-activating protein 4

Source gene: ARHGAP4

Class: DEG_SPOP_SBC_1

Location: 200:204

E3 ligase: SPOP

DEGRON score: 0.9213

ASA_SCORE: 83.22

COIL: 0.9174

CONS_SCORE: 0.2729

DSS_SCORE: 0.6786

HELIX: 0.0542

FCONS_SCORE: 0.8494

RIG_SCORE: 0.6527

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G211R	TCGA-55-7281	LUAD	TCGA	VPTTT	DEG_SPOP_SBC_1	0.1389
p.R214C	TCGA-77-A5GH	LUSC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.0556
p.R214C	TCGA-KN-8428	KICH	TCGA	VPTTT	DEG_SPOP_SBC_1	0.0556
p.S199I	TCGA-D1-A103	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.75
p.A205S	TCGA-EL-A4K7	THCA	TCGA	VPTTT	DEG_SPOP_SBC_1	0.3056
p.E192K	TCGA-WE-A8K4	SKCM	TCGA	VPTTT	DEG_SPOP_SBC_1	0.1111
p.R193C	DO220484	KICH	ICGC	VPTTT	DEG_SPOP_SBC_1	0.1389
p.R193C	DO45452	LUSC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.1389
p.G190R	DO25985	LUAD	ICGC	VPTTT	DEG_SPOP_SBC_1	0.0556
p.S196F	DO47389	SKCM	ICGC	VPTTT	DEG_SPOP_SBC_1	0.2222
p.R207L	DO37946	SKCM	ICGC	VPTTT	DEG_SPOP_SBC_1	0.25
p.L197I	DO38075	SKCM	ICGC	VPTTT	DEG_SPOP_SBC_1	0.25
p.R214H	SIDM00680	Colorectal Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.0556
p.R214H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VPTTT	DEG_SPOP_SBC_1	0.0556
p.R214H	SIDM00220	Ovarian Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.0556
p.R214H	ACH-000957	Colon/Colorectal Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	0.0556
p.R214H	ACH-000962	Ovarian Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	0.0556
p.R214H	ACH-001145	Ovarian Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	0.0556
p.R214H	OC-314	ovary	COSMIC	VPTTT	DEG_SPOP_SBC_1	0.0556
p.R214H	LS-180	large_intestine	COSMIC	VPTTT	DEG_SPOP_SBC_1	0.0556
p.P201S	SIDM00861	Ovarian Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.5641
p.P201S	ACH-000906	Ovarian Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	0.5641
p.P201S	ES-2	ovary	COSMIC	VPTTT	DEG_SPOP_SBC_1	0.5641
p.R193H	LS-180	large_intestine	COSMIC	VPTTT	DEG_SPOP_SBC_1	0.1389
p.R193H	OC-314	ovary	COSMIC	VPTTT	DEG_SPOP_SBC_1	0.1389
p.S199R	BPH-1	prostate	COSMIC	VPTTT	DEG_SPOP_SBC_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75829	Leukocyte cell-derived chemotaxin 1	DEG_SPOP_SBC_1	221:225	VPTTT	SPOP	0.9724	More...
P22105	Tenascin-X	DEG_SPOP_SBC_1	2834:2838	VPTTT	SPOP	0.8867	More...
P98171	Rho GTPase-activating protein 4	DEG_SPOP_SBC_1	200:204	VPTTT	SPOP	0.9213	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5806:5810	VPTTT	SPOP	0.9863	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11618:11622	VPTTT	SPOP	0.7076	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	150:154	VPTTT	SPOP	0.9885	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	161:165	VPTTT	SPOP	0.986	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	190:194	VPTTT	SPOP	0.9092	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2051:2055	VPTTT	SPOP	0.9951	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3308:3312	VPTTT	SPOP	0.993	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3865:3869	VPTTT	SPOP	0.9882	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4593:4597	VPTTT	SPOP	0.9609	More...
Q9UL68	Myelin transcription factor 1-like protein	DEG_SPOP_SBC_1	625:629	VPTTT	SPOP	0.8307	More...
Q9UPN9	E3 ubiquitin-protein ligase TRIM33	DEG_SPOP_SBC_1	543:547	VPTTT	SPOP	0.7751	More...
O94880	PHD finger protein 14	DEG_SPOP_SBC_1	166:170	VPTTT	SPOP	0.991	More...
Q8WW62	Transmembrane emp24 domain-containing protein 6	DEG_SPOP_SBC_1	229:233	VPTTT	SPOP	0.7106	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons