DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 2051:2055

E3 ligase: SPOP

DEGRON score: 0.9951

ASA_SCORE: 88.64

COIL: 0.9242

CONS_SCORE: 0.2099

DSS_SCORE: 0.5978

HELIX: 0.014

FCONS_SCORE: 1.0038

RIG_SCORE: 0.723

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2062I	TCGA-24-1427	OV	TCGA	VPTTT	DEG_SPOP_SBC_1	0.1389
p.G2058A	TCGA-55-8094	LUAD	TCGA	VPTTT	DEG_SPOP_SBC_1	0.25
p.P2063T	TCGA-77-8156	LUSC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.1111
p.T2056N	TCGA-CM-4746	COAD	TCGA	VPTTT	DEG_SPOP_SBC_1	0.3056
p.A2046V	TCGA-HU-A4HD	STAD	TCGA	VPTTT	DEG_SPOP_SBC_1	0.1944
p.T2045N	DO48551	BLCA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.1667
p.T2059N	DO7882	COAD	ICGC	VPTTT	DEG_SPOP_SBC_1	0.2222
p.G2061A	DO24150	LUAD	ICGC	VPTTT	DEG_SPOP_SBC_1	0.1667
p.T2057S	DO230961	LUSC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.2778
p.T2057S	DO224594	LUSC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.2778
p.P2055A	DO224563	LUSC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7503
p.T2065I	DO28471	OV	ICGC	VPTTT	DEG_SPOP_SBC_1	0.0556
p.A2049V	DO47989	STAD	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7222
p.G2044E	SIDM00545	Melanoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.1389
p.G2044E	ACH-000987	Skin Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	0.1389
p.G2044E	Mewo	skin	COSMIC	VPTTT	DEG_SPOP_SBC_1	0.1389
p.S2065F	SIDM00007	Other Solid Cancers	GDSC	VPTTT	DEG_SPOP_SBC_1	0.0556
p.S2065F	ACH-001550	Skin Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	0.0556
p.S2065F	MCC13	skin	COSMIC	VPTTT	DEG_SPOP_SBC_1	0.0556
p.P2043T	SIDM00951	T-Lymphoblastic Leukemia	GDSC	VPTTT	DEG_SPOP_SBC_1	0.1111
p.P2043T	ACH-002222	Leukemia	CCLE	VPTTT	DEG_SPOP_SBC_1	0.1111
p.P2043T	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	VPTTT	DEG_SPOP_SBC_1	0.1111
p.T2045R	SIDM01763	Rhabdomyosarcoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75829	Leukocyte cell-derived chemotaxin 1	DEG_SPOP_SBC_1	221:225	VPTTT	SPOP	0.9724	More...
P22105	Tenascin-X	DEG_SPOP_SBC_1	2834:2838	VPTTT	SPOP	0.8867	More...
P98171	Rho GTPase-activating protein 4	DEG_SPOP_SBC_1	200:204	VPTTT	SPOP	0.9213	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5806:5810	VPTTT	SPOP	0.9863	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11618:11622	VPTTT	SPOP	0.7076	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	150:154	VPTTT	SPOP	0.9885	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	161:165	VPTTT	SPOP	0.986	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	190:194	VPTTT	SPOP	0.9092	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2051:2055	VPTTT	SPOP	0.9951	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3308:3312	VPTTT	SPOP	0.993	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3865:3869	VPTTT	SPOP	0.9882	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4593:4597	VPTTT	SPOP	0.9609	More...
Q9UL68	Myelin transcription factor 1-like protein	DEG_SPOP_SBC_1	625:629	VPTTT	SPOP	0.8307	More...
Q9UPN9	E3 ubiquitin-protein ligase TRIM33	DEG_SPOP_SBC_1	543:547	VPTTT	SPOP	0.7751	More...
O94880	PHD finger protein 14	DEG_SPOP_SBC_1	166:170	VPTTT	SPOP	0.991	More...
Q8WW62	Transmembrane emp24 domain-containing protein 6	DEG_SPOP_SBC_1	229:233	VPTTT	SPOP	0.7106	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons