DegronMD

Uniprot ID: Q8WW62

Source protein: Transmembrane emp24 domain-containing protein 6

Source gene: TMED6

Class: DEG_SPOP_SBC_1

Location: 229:233

E3 ligase: SPOP

DEGRON score: 0.7106

ASA_SCORE: 88.46

COIL: 0.946

CONS_SCORE: 0.4401

DSS_SCORE: 0.2086

HELIX: 0.0182

FCONS_SCORE: 0.7676

RIG_SCORE: 0.7993

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R225H	TCGA-AX-A06H	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.2222
p.R225H	TCGA-B5-A3FC	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.2222
p.R225H	DO233267	GACA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.2222
p.R225H	DO43530	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.2222
p.R225H	DO41871	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.2222
p.K236N	TCGA-B5-A0JY	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.3611
p.K236N	DO43041	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.3611
p.F222V	TCGA-ZF-A9RC	BLCA	TCGA	VPTTT	DEG_SPOP_SBC_1	0.1389
p.F222V	DO219068	BLCA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.1389
p.L223S	DO233884	GACA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.1667
p.T232N	DO228986	LICA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7055
p.N228S	SIDM00392	Melanoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.3056
p.N228S	SIDM00429	B-Lymphoblastic Leukemia	GDSC	VPTTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75829	Leukocyte cell-derived chemotaxin 1	DEG_SPOP_SBC_1	221:225	VPTTT	SPOP	0.9724	More...
P22105	Tenascin-X	DEG_SPOP_SBC_1	2834:2838	VPTTT	SPOP	0.8867	More...
P98171	Rho GTPase-activating protein 4	DEG_SPOP_SBC_1	200:204	VPTTT	SPOP	0.9213	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5806:5810	VPTTT	SPOP	0.9863	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11618:11622	VPTTT	SPOP	0.7076	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	150:154	VPTTT	SPOP	0.9885	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	161:165	VPTTT	SPOP	0.986	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	190:194	VPTTT	SPOP	0.9092	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2051:2055	VPTTT	SPOP	0.9951	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3308:3312	VPTTT	SPOP	0.993	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3865:3869	VPTTT	SPOP	0.9882	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4593:4597	VPTTT	SPOP	0.9609	More...
Q9UL68	Myelin transcription factor 1-like protein	DEG_SPOP_SBC_1	625:629	VPTTT	SPOP	0.8307	More...
Q9UPN9	E3 ubiquitin-protein ligase TRIM33	DEG_SPOP_SBC_1	543:547	VPTTT	SPOP	0.7751	More...
O94880	PHD finger protein 14	DEG_SPOP_SBC_1	166:170	VPTTT	SPOP	0.991	More...
Q8WW62	Transmembrane emp24 domain-containing protein 6	DEG_SPOP_SBC_1	229:233	VPTTT	SPOP	0.7106	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons