DegronMD

Uniprot ID: Q96D42

Source protein: Hepatitis A virus cellular receptor 1

Source gene: HAVCR1

Class: DEG_SPOP_SBC_1

Location: 190:194

E3 ligase: SPOP

DEGRON score: 0.9092

ASA_SCORE: 90.56

COIL: 0.909

CONS_SCORE: 0.3368

DSS_SCORE: 0.4782

HELIX: 0.0158

FCONS_SCORE: 0.9237

RIG_SCORE: 0.7549

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P191Q	TCGA-63-A5MT	LUSC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.5924
p.P191Q	DO219163	LUSC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.5924
p.S189I	TCGA-BS-A0UF	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.3056
p.S189I	DO41488	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.3056
p.T193P	TCGA-DU-6392	LGG	TCGA	VPTTT	DEG_SPOP_SBC_1	0.7031
p.T193P	DO22237	LGG	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7031
p.M182I	TCGA-EO-A22U	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.1111
p.M182I	TCGA-UT-A88C	MESO	TCGA	VPTTT	DEG_SPOP_SBC_1	0.1111
p.M182I	DO43755	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.1111
p.S195R	DO223007	ESCA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.3056
p.T181K	DO228976	LICA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.0833
p.T180K	DO229038	LICA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.0556
p.T194M	SIDM01040	Ovarian Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.7423
p.T194M	SIDM00878	Breast Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.7423
p.T194M	SIDM00785	Acute Myeloid Leukemia	GDSC	VPTTT	DEG_SPOP_SBC_1	0.7423
p.V190I	SIDM01088	Endometrial Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.7076
p.V190I	ACH-000965	Endometrial/Uterine Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	0.7076
p.V190I	ACH-000979	Prostate Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	0.7076
p.V190I	RL95-2	endometrium	COSMIC	VPTTT	DEG_SPOP_SBC_1	0.7076

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75829	Leukocyte cell-derived chemotaxin 1	DEG_SPOP_SBC_1	221:225	VPTTT	SPOP	0.9724	More...
P22105	Tenascin-X	DEG_SPOP_SBC_1	2834:2838	VPTTT	SPOP	0.8867	More...
P98171	Rho GTPase-activating protein 4	DEG_SPOP_SBC_1	200:204	VPTTT	SPOP	0.9213	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5806:5810	VPTTT	SPOP	0.9863	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11618:11622	VPTTT	SPOP	0.7076	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	150:154	VPTTT	SPOP	0.9885	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	161:165	VPTTT	SPOP	0.986	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	190:194	VPTTT	SPOP	0.9092	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2051:2055	VPTTT	SPOP	0.9951	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3308:3312	VPTTT	SPOP	0.993	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3865:3869	VPTTT	SPOP	0.9882	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4593:4597	VPTTT	SPOP	0.9609	More...
Q9UL68	Myelin transcription factor 1-like protein	DEG_SPOP_SBC_1	625:629	VPTTT	SPOP	0.8307	More...
Q9UPN9	E3 ubiquitin-protein ligase TRIM33	DEG_SPOP_SBC_1	543:547	VPTTT	SPOP	0.7751	More...
O94880	PHD finger protein 14	DEG_SPOP_SBC_1	166:170	VPTTT	SPOP	0.991	More...
Q8WW62	Transmembrane emp24 domain-containing protein 6	DEG_SPOP_SBC_1	229:233	VPTTT	SPOP	0.7106	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons