DegronMD

Uniprot ID: Q9UL68

Source protein: Myelin transcription factor 1-like protein

Source gene: MYT1L

Class: DEG_SPOP_SBC_1

Location: 625:629

E3 ligase: SPOP

DEGRON score: 0.8307

ASA_SCORE: 74.24

COIL: 0.9026

CONS_SCORE: 0.5271

DSS_SCORE: 0.4825

HELIX: 0.0184

FCONS_SCORE: 1.1299

RIG_SCORE: 0.7455

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E635G	TCGA-24-1845	OV	TCGA	VPTTT	DEG_SPOP_SBC_1	0.1667
p.E635G	DO29920	OV	ICGC	VPTTT	DEG_SPOP_SBC_1	0.1667
p.Y639S	TCGA-33-4582	LUSC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.0556
p.Y639S	DO26698	LUSC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.0556
p.T626S	TCGA-52-7812	LUSC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.7116
p.T626S	DO27067	LUSC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7116
p.N631I	TCGA-98-8022	LUSC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.2778
p.N631I	DO26934	LUSC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.2778
p.T627M	TCGA-A6-5659	COAD	TCGA	VPTTT	DEG_SPOP_SBC_1	0.7423
p.T627M	TCGA-DF-A2KU	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.7423
p.T627M	TCGA-FI-A2D0	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.7423
p.T627M	TCGA-RD-A8NB	STAD	TCGA	VPTTT	DEG_SPOP_SBC_1	0.7423
p.T627M	DO9860	COAD	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7423
p.T627M	DO50142	STAD	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7423
p.T627M	DO223286	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7423
p.T627M	DO43891	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7423
p.R629C	TCGA-AX-A2HD	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.8301
p.R629C	TCGA-CM-4751	COAD	TCGA	VPTTT	DEG_SPOP_SBC_1	0.8301
p.R629C	DO7866	COAD	ICGC	VPTTT	DEG_SPOP_SBC_1	0.8301
p.R629C	DO42608	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.8301
p.P624H	TCGA-BF-A1PZ	SKCM	TCGA	VPTTT	DEG_SPOP_SBC_1	0.3056
p.P624H	DO50279	SKCM	ICGC	VPTTT	DEG_SPOP_SBC_1	0.3056
p.T627R	TCGA-CN-4727	HNSC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.7876
p.T627R	DO14258	HNSC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7876
p.N631S	TCGA-DI-A1BU	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.2778
p.N631S	DO42023	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.2778
p.T626A	TCGA-DI-A1BU	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.7139
p.T626A	DO42023	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7139
p.P628S	TCGA-EO-A22R	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.6752
p.P628S	DO42713	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.6752
p.P615H	TCGA-F5-6814	READ	TCGA	VPTTT	DEG_SPOP_SBC_1	0.0556
p.P615H	DO36556	READ	ICGC	VPTTT	DEG_SPOP_SBC_1	0.0556
p.E637Q	TCGA-FD-A3SS	BLCA	TCGA	VPTTT	DEG_SPOP_SBC_1	0.1111
p.E637Q	DO737	BLCA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.1111
p.N622T	TCGA-FI-A2D5	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.25
p.N622T	DO41331	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.25
p.P628Q	TCGA-FS-A1ZG	SKCM	TCGA	VPTTT	DEG_SPOP_SBC_1	0.7035
p.P628Q	DO37523	SKCM	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7035
p.P628T	DO228952	LICA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7031
p.T627K	DO229037	LICA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7306
p.L636I	DO229009	LICA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.25
p.L636I	ACH-000991	Colon/Colorectal Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	0.25
p.L636I	SNU-81	large_intestine	COSMIC	VPTTT	DEG_SPOP_SBC_1	0.25
p.N622K	DO48732	LIRI	ICGC	VPTTT	DEG_SPOP_SBC_1	0.25
p.E637K	DO229072	PRAD	ICGC	VPTTT	DEG_SPOP_SBC_1	0.1111
p.P630L	SIDM01966	Colorectal Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.3056
p.L638I	SIDM00193	Colorectal Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.0833
p.L638I	SNU-81	large_intestine	COSMIC	VPTTT	DEG_SPOP_SBC_1	0.0833
p.R631H	SIDM01611	Endometrial Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.2778
p.R629H	ACH-000996	Endometrial/Uterine Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75829	Leukocyte cell-derived chemotaxin 1	DEG_SPOP_SBC_1	221:225	VPTTT	SPOP	0.9724	More...
P22105	Tenascin-X	DEG_SPOP_SBC_1	2834:2838	VPTTT	SPOP	0.8867	More...
P98171	Rho GTPase-activating protein 4	DEG_SPOP_SBC_1	200:204	VPTTT	SPOP	0.9213	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5806:5810	VPTTT	SPOP	0.9863	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11618:11622	VPTTT	SPOP	0.7076	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	150:154	VPTTT	SPOP	0.9885	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	161:165	VPTTT	SPOP	0.986	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	190:194	VPTTT	SPOP	0.9092	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2051:2055	VPTTT	SPOP	0.9951	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3308:3312	VPTTT	SPOP	0.993	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3865:3869	VPTTT	SPOP	0.9882	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4593:4597	VPTTT	SPOP	0.9609	More...
Q9UL68	Myelin transcription factor 1-like protein	DEG_SPOP_SBC_1	625:629	VPTTT	SPOP	0.8307	More...
Q9UPN9	E3 ubiquitin-protein ligase TRIM33	DEG_SPOP_SBC_1	543:547	VPTTT	SPOP	0.7751	More...
O94880	PHD finger protein 14	DEG_SPOP_SBC_1	166:170	VPTTT	SPOP	0.991	More...
Q8WW62	Transmembrane emp24 domain-containing protein 6	DEG_SPOP_SBC_1	229:233	VPTTT	SPOP	0.7106	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPTTT

Degron related mutations and impact score

Drug responses associated with MYT1L mutations

All proteins holding degron of VPTTT