DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 4593:4597

E3 ligase: SPOP

DEGRON score: 0.9609

ASA_SCORE: 88.04

COIL: 0.9066

CONS_SCORE: 0.2929

DSS_SCORE: 0.5952

HELIX: 0.0162

FCONS_SCORE: 0.9743

RIG_SCORE: 0.723

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G4600D	TCGA-86-8673	LUAD	TCGA	VPTTT	DEG_SPOP_SBC_1	0.25
p.G4600D	TCGA-B5-A3FC	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.25
p.P4605S	TCGA-AD-5900	COAD	TCGA	VPTTT	DEG_SPOP_SBC_1	0.1111
p.S4607F	TCGA-EE-A3JD	SKCM	TCGA	VPTTT	DEG_SPOP_SBC_1	0.0556
p.V4593M	TCGA-ZG-A9N3	PRAD	TCGA	VPTTT	DEG_SPOP_SBC_1	0.7208
p.G4603D	DO26260	LUAD	ICGC	VPTTT	DEG_SPOP_SBC_1	0.1667
p.G4603D	DO41871	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.1667
p.G4603S	DO220896	MELA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.1667
p.V4596M	DO219446	PRAD	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7208
p.A4606V	DO229257	THCA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.0833
p.T4599M	SIDM00656	Burkitt's Lymphoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.2778
p.T4599M	SIDM00309	Mesothelioma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.2778
p.T4599M	SIDM00431	T-Lymphoblastic Leukemia	GDSC	VPTTT	DEG_SPOP_SBC_1	0.2778
p.T4599M	SIDM01681	Non-Cancerous	GDSC	VPTTT	DEG_SPOP_SBC_1	0.2778
p.T4599M	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.2778
p.T4599M	SIDM00641	Burkitt's Lymphoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75829	Leukocyte cell-derived chemotaxin 1	DEG_SPOP_SBC_1	221:225	VPTTT	SPOP	0.9724	More...
P22105	Tenascin-X	DEG_SPOP_SBC_1	2834:2838	VPTTT	SPOP	0.8867	More...
P98171	Rho GTPase-activating protein 4	DEG_SPOP_SBC_1	200:204	VPTTT	SPOP	0.9213	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5806:5810	VPTTT	SPOP	0.9863	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11618:11622	VPTTT	SPOP	0.7076	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	150:154	VPTTT	SPOP	0.9885	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	161:165	VPTTT	SPOP	0.986	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	190:194	VPTTT	SPOP	0.9092	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2051:2055	VPTTT	SPOP	0.9951	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3308:3312	VPTTT	SPOP	0.993	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3865:3869	VPTTT	SPOP	0.9882	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4593:4597	VPTTT	SPOP	0.9609	More...
Q9UL68	Myelin transcription factor 1-like protein	DEG_SPOP_SBC_1	625:629	VPTTT	SPOP	0.8307	More...
Q9UPN9	E3 ubiquitin-protein ligase TRIM33	DEG_SPOP_SBC_1	543:547	VPTTT	SPOP	0.7751	More...
O94880	PHD finger protein 14	DEG_SPOP_SBC_1	166:170	VPTTT	SPOP	0.991	More...
Q8WW62	Transmembrane emp24 domain-containing protein 6	DEG_SPOP_SBC_1	229:233	VPTTT	SPOP	0.7106	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons