DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VPTTT
Uniprot ID:
O75829
Source protein:
Leukocyte cell-derived chemotaxin 1
Source gene:
CNMD
Class:
DEG_SPOP_SBC_1
Location:
221:225
E3 ligase:
SPOP
DEGRON score:
0.9724
ASA_SCORE:
96.02
COIL:
0.9256
CONS_SCORE:
0.2495
DSS_SCORE:
0.6538
HELIX:
0.021
FCONS_SCORE:
0.7239
RIG_SCORE:
0.693
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CNMD mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VPTTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O75829
Leukocyte cell-derived chemotaxin 1
DEG_SPOP_SBC_1
221:225
VPTTT
SPOP
0.9724
More...
P22105
Tenascin-X
DEG_SPOP_SBC_1
2834:2838
VPTTT
SPOP
0.8867
More...
P98171
Rho GTPase-activating protein 4
DEG_SPOP_SBC_1
200:204
VPTTT
SPOP
0.9213
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
5806:5810
VPTTT
SPOP
0.9863
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
11618:11622
VPTTT
SPOP
0.7076
More...
Q96D42
Hepatitis A virus cellular receptor 1
DEG_SPOP_SBC_1
150:154
VPTTT
SPOP
0.9885
More...
Q96D42
Hepatitis A virus cellular receptor 1
DEG_SPOP_SBC_1
161:165
VPTTT
SPOP
0.986
More...
Q96D42
Hepatitis A virus cellular receptor 1
DEG_SPOP_SBC_1
190:194
VPTTT
SPOP
0.9092
More...
Q9HC84
Mucin-5B
DEG_SPOP_SBC_1
2051:2055
VPTTT
SPOP
0.9951
More...
Q9HC84
Mucin-5B
DEG_SPOP_SBC_1
3308:3312
VPTTT
SPOP
0.993
More...
Q9HC84
Mucin-5B
DEG_SPOP_SBC_1
3865:3869
VPTTT
SPOP
0.9882
More...
Q9HC84
Mucin-5B
DEG_SPOP_SBC_1
4593:4597
VPTTT
SPOP
0.9609
More...
Q9UL68
Myelin transcription factor 1-like protein
DEG_SPOP_SBC_1
625:629
VPTTT
SPOP
0.8307
More...
Q9UPN9
E3 ubiquitin-protein ligase TRIM33
DEG_SPOP_SBC_1
543:547
VPTTT
SPOP
0.7751
More...
O94880
PHD finger protein 14
DEG_SPOP_SBC_1
166:170
VPTTT
SPOP
0.991
More...
Q8WW62
Transmembrane emp24 domain-containing protein 6
DEG_SPOP_SBC_1
229:233
VPTTT
SPOP
0.7106
More...