DegronMD - Q8WW62(TMED6)

TMED6

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R225H	TCGA-AX-A06H	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.2222
p.R225H	TCGA-B5-A3FC	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.2222
p.R225H	DO233267	GACA	ICGC	VPTTT	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.2222
p.R225H	DO43530	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.2222
p.R225H	DO41871	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.2222
p.K236N	TCGA-B5-A0JY	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	229:233	Mutation substituting flanking lysine	0.3611
p.K236N	DO43041	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	229:233	Mutation substituting flanking lysine	0.3611
p.F222V	TCGA-ZF-A9RC	BLCA	TCGA	VPTTT	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1389
p.F222V	DO219068	BLCA	ICGC	VPTTT	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1389
p.L223S	DO233884	GACA	ICGC	VPTTT	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1667
p.T232N	DO228986	LICA	ICGC	VPTTT	DEG_SPOP_SBC_1	229:233	Mutation altering degron motif	0.7055
p.N228S	SIDM00392	Melanoma	GDSC	VPTTT	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.3056
p.N228S	SIDM00429	B-Lymphoblastic Leukemia	GDSC	VPTTT	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc