DegronMD

Uniprot ID: Q96D42

Source protein: Hepatitis A virus cellular receptor 1

Source gene: HAVCR1

Class: DEG_SCF_FBW7_1

Location: 129:136

E3 ligase: FBXW7

DEGRON score: 0.7027

ASA_SCORE: 94.2375

COIL: 0.936

CONS_SCORE: 0.2997

DSS_SCORE: 0.3015

HELIX: 0.0111

FCONS_SCORE: 0.9225

RIG_SCORE: 0.8222

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T130M	TCGA-AA-3877	COAD	TCGA	VTTTPIVT	DEG_SCF_FBW7_1	0.6312
p.T130M	TCGA-EY-A549	UCEC	TCGA	VTTTPIVT	DEG_SCF_FBW7_1	0.6312
p.T130M	DO7855	COAD	ICGC	VTTTPIVT	DEG_SCF_FBW7_1	0.6312
p.T130M	DO48174	UCEC	ICGC	VTTTPIVT	DEG_SCF_FBW7_1	0.6312
p.I134V	TCGA-2Y-A9HA	LIHC	TCGA	VTTTPIVT	DEG_SCF_FBW7_1	0.5965
p.I134V	DO219539	LIHC	ICGC	VTTTPIVT	DEG_SCF_FBW7_1	0.5965
p.P126L	SIDM00504	Glioma	GDSC	VTTTPIVT	DEG_SCF_FBW7_1	0.25
p.P126L	ACH-001126	Brain Cancer	CCLE	VTTTPIVT	DEG_SCF_FBW7_1	0.25
p.P126L	MOG-G-UVW	central_nervous_system	COSMIC	VTTTPIVT	DEG_SCF_FBW7_1	0.25
p.T140I	TCGA-B0-4698	KIRC	TCGA	VTTTPIVT	DEG_SCF_FBW7_1	0.2222
p.T140I	DO20368	KIRC	ICGC	VTTTPIVT	DEG_SCF_FBW7_1	0.2222
p.V141I	TCGA-A5-A0G2	UCEC	TCGA	VTTTPIVT	DEG_SCF_FBW7_1	0.1944
p.V141I	TCGA-AZ-6598	COAD	TCGA	VTTTPIVT	DEG_SCF_FBW7_1	0.1944
p.V141I	TCGA-D1-A0ZO	UCEC	TCGA	VTTTPIVT	DEG_SCF_FBW7_1	0.1944
p.V141I	DO10276	COAD	ICGC	VTTTPIVT	DEG_SCF_FBW7_1	0.1944
p.V141I	DO233205	GACA	ICGC	VTTTPIVT	DEG_SCF_FBW7_1	0.1944
p.V141I	DO41927	UCEC	ICGC	VTTTPIVT	DEG_SCF_FBW7_1	0.1944
p.V141I	DO41235	UCEC	ICGC	VTTTPIVT	DEG_SCF_FBW7_1	0.1944
p.E123K	TCGA-FR-A726	SKCM	TCGA	VTTTPIVT	DEG_SCF_FBW7_1	0.1667
p.E123K	DO222632	MELA	ICGC	VTTTPIVT	DEG_SCF_FBW7_1	0.1667
p.E123K	DO48665	SKCM	ICGC	VTTTPIVT	DEG_SCF_FBW7_1	0.1667
p.T142M	SIDM00837	Colorectal Carcinoma	GDSC	VTTTPIVT	DEG_SCF_FBW7_1	0.1667
p.T142M	ACH-000958	Colon/Colorectal Cancer	CCLE	VTTTPIVT	DEG_SCF_FBW7_1	0.1667
p.T142M	SW48	large_intestine	COSMIC	VTTTPIVT	DEG_SCF_FBW7_1	0.1667
p.V120I	TCGA-QQ-A5V9	SARC	TCGA	VTTTPIVT	DEG_SCF_FBW7_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SCF_FBW7_1	129:136	VTTTPIVT	FBXW7	0.7027	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons