DegronMD

Uniprot ID: Q96D42

Source protein: Hepatitis A virus cellular receptor 1

Source gene: HAVCR1

Class: DEG_SPOP_SBC_1

Location: 144:148

E3 ligase: SPOP

DEGRON score: 0.9891

ASA_SCORE: 111.96

COIL: 0.9654

CONS_SCORE: 0.2257

DSS_SCORE: 0.4191

HELIX: 0.0096

FCONS_SCORE: 0.9642

RIG_SCORE: 0.8041

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T148N	TCGA-17-Z059	LUAD	TCGA	VRTST	DEG_SPOP_SBC_1	0.7055
p.V141I	TCGA-A5-A0G2	UCEC	TCGA	VRTST	DEG_SPOP_SBC_1	0.25
p.V141I	TCGA-AZ-6598	COAD	TCGA	VRTST	DEG_SPOP_SBC_1	0.25
p.V141I	TCGA-D1-A0ZO	UCEC	TCGA	VRTST	DEG_SPOP_SBC_1	0.25
p.V141I	DO10276	COAD	ICGC	VRTST	DEG_SPOP_SBC_1	0.25
p.V141I	DO233205	GACA	ICGC	VRTST	DEG_SPOP_SBC_1	0.25
p.V141I	DO41927	UCEC	ICGC	VRTST	DEG_SPOP_SBC_1	0.25
p.V141I	DO41235	UCEC	ICGC	VRTST	DEG_SPOP_SBC_1	0.25
p.R145Q	TCGA-AG-A002	READ	TCGA	VRTST	DEG_SPOP_SBC_1	0.6218
p.R145Q	TCGA-EE-A2GD	SKCM	TCGA	VRTST	DEG_SPOP_SBC_1	0.6218
p.R145Q	DO229459	SKCA	ICGC	VRTST	DEG_SPOP_SBC_1	0.6218
p.R145Q	DO37603	SKCM	ICGC	VRTST	DEG_SPOP_SBC_1	0.6218
p.T140I	TCGA-B0-4698	KIRC	TCGA	VRTST	DEG_SPOP_SBC_1	0.2222
p.T140I	DO20368	KIRC	ICGC	VRTST	DEG_SPOP_SBC_1	0.2222
p.S147R	TCGA-BR-8363	STAD	TCGA	VRTST	DEG_SPOP_SBC_1	0.7427
p.S147R	DO47837	STAD	ICGC	VRTST	DEG_SPOP_SBC_1	0.7427
p.T146R	TCGA-CV-6938	HNSC	TCGA	VRTST	DEG_SPOP_SBC_1	0.7876
p.T146R	DO14462	HNSC	ICGC	VRTST	DEG_SPOP_SBC_1	0.7876
p.R145L	TCGA-L9-A8F4	LUAD	TCGA	VRTST	DEG_SPOP_SBC_1	0.7316
p.R145L	DO49876	LUAD	ICGC	VRTST	DEG_SPOP_SBC_1	0.7316
p.M158T	DO224820	COCA	ICGC	VRTST	DEG_SPOP_SBC_1	0.0556
p.M158T	DO52361	LUSC	ICGC	VRTST	DEG_SPOP_SBC_1	0.0556
p.T146K	DO229041	LICA	ICGC	VRTST	DEG_SPOP_SBC_1	0.7306
p.S147C	DO50972	LICA	ICGC	VRTST	DEG_SPOP_SBC_1	0.7541
p.T148S	DO51491	PACA	ICGC	VRTST	DEG_SPOP_SBC_1	0.6005
p.M158I	DO229272	THCA	ICGC	VRTST	DEG_SPOP_SBC_1	0.0556
p.M158I	DO229245	THCA	ICGC	VRTST	DEG_SPOP_SBC_1	0.0556
p.T155N	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	VRTST	DEG_SPOP_SBC_1	0.1389
p.T155N	ACH-001363	Lung Cancer	CCLE	VRTST	DEG_SPOP_SBC_1	0.1389
p.T155N	NCI-H2135	lung	COSMIC	VRTST	DEG_SPOP_SBC_1	0.1389
p.T142M	SIDM00837	Colorectal Carcinoma	GDSC	VRTST	DEG_SPOP_SBC_1	0.2778
p.T142M	ACH-000958	Colon/Colorectal Cancer	CCLE	VRTST	DEG_SPOP_SBC_1	0.2778
p.T142M	SW48	large_intestine	COSMIC	VRTST	DEG_SPOP_SBC_1	0.2778
p.T155P	ACH-001433	Sarcoma	CCLE	VRTST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2TAC2	Coiled-coil domain-containing protein 57	DEG_SPOP_SBC_1	620:624	VRTST	SPOP	0.5097	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	144:148	VRTST	SPOP	0.9891	More...
Q9UK17	Potassium voltage-gated channel subfamily D member 3	DEG_SPOP_SBC_1	500:504	VRTST	SPOP	0.8401	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRTST

Degron related mutations and impact score

Drug responses associated with HAVCR1 mutations

All proteins holding degron of VRTST