DegronMD

Uniprot ID: Q2TAC2

Source protein: Coiled-coil domain-containing protein 57

Source gene: CCDC57

Class: DEG_SPOP_SBC_1

Location: 620:624

E3 ligase: SPOP

DEGRON score: 0.5097

ASA_SCORE: 100.66

COIL: 0.7762

CONS_SCORE: 0.2439

DSS_SCORE: 0.7452

HELIX: 0.21

FCONS_SCORE: 0.9549

RIG_SCORE: 0.633

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S619T	TCGA-A4-7828	KIRP	TCGA	VRTST	DEG_SPOP_SBC_1	0.3056
p.S619T	DO20760	KIRP	ICGC	VRTST	DEG_SPOP_SBC_1	0.3056
p.G634D	TCGA-CV-A6K2	HNSC	TCGA	VRTST	DEG_SPOP_SBC_1	0.0556
p.G634D	DO52079	HNSC	ICGC	VRTST	DEG_SPOP_SBC_1	0.0556
p.Q632K	TCGA-FS-A1Z4	SKCM	TCGA	VRTST	DEG_SPOP_SBC_1	0.1111
p.Q632K	DO37462	SKCM	ICGC	VRTST	DEG_SPOP_SBC_1	0.1111
p.S630Y	DO229045	LICA	ICGC	VRTST	DEG_SPOP_SBC_1	0.1667
p.S619I	DO232224	PBCA	ICGC	VRTST	DEG_SPOP_SBC_1	0.3056
p.R621C	DO229216	THCA	ICGC	VRTST	DEG_SPOP_SBC_1	0.719
p.T626M	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VRTST	DEG_SPOP_SBC_1	0.2778
p.T626M	SIDM00203	Ewing's Sarcoma	GDSC	VRTST	DEG_SPOP_SBC_1	0.2778
p.V620G	SIDM01190	Bladder Carcinoma	GDSC	VRTST	DEG_SPOP_SBC_1	0.7532
p.V620G	ACH-000720	Bladder Cancer	CCLE	VRTST	DEG_SPOP_SBC_1	0.7532
p.V620G	TCCSUP	urinary_tract	COSMIC	VRTST	DEG_SPOP_SBC_1	0.7532

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2TAC2	Coiled-coil domain-containing protein 57	DEG_SPOP_SBC_1	620:624	VRTST	SPOP	0.5097	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	144:148	VRTST	SPOP	0.9891	More...
Q9UK17	Potassium voltage-gated channel subfamily D member 3	DEG_SPOP_SBC_1	500:504	VRTST	SPOP	0.8401	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons