DegronMD

Uniprot ID: Q9UK17

Source protein: Potassium voltage-gated channel subfamily D member 3

Source gene: KCND3

Class: DEG_SPOP_SBC_1

Location: 500:504

E3 ligase: SPOP

DEGRON score: 0.8401

ASA_SCORE: 89.38

COIL: 0.7902

CONS_SCORE: 0.3405

DSS_SCORE: 0.2358

HELIX: 0.1324

FCONS_SCORE: 1.0206

RIG_SCORE: 0.7941

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E509K	TCGA-19-5956	GBM	TCGA	VRTST	DEG_SPOP_SBC_1	0.1944
p.E509K	TCGA-AG-A002	READ	TCGA	VRTST	DEG_SPOP_SBC_1	0.1944
p.L492I	TCGA-B5-A1MR	UCEC	TCGA	VRTST	DEG_SPOP_SBC_1	0.1111
p.L492I	DO41758	UCEC	ICGC	VRTST	DEG_SPOP_SBC_1	0.1111
p.I505M	TCGA-C8-A26X	BRCA	TCGA	VRTST	DEG_SPOP_SBC_1	0.3056
p.I505M	TCGA-DK-AA71	BLCA	TCGA	VRTST	DEG_SPOP_SBC_1	0.3056
p.I505M	DO219010	BLCA	ICGC	VRTST	DEG_SPOP_SBC_1	0.3056
p.I505M	DO5549	BRCA	ICGC	VRTST	DEG_SPOP_SBC_1	0.3056
p.R501Q	TCGA-DA-A1IC	SKCM	TCGA	VRTST	DEG_SPOP_SBC_1	0.6218
p.R501Q	DO233764	GACA	ICGC	VRTST	DEG_SPOP_SBC_1	0.6218
p.R501Q	DO37430	SKCM	ICGC	VRTST	DEG_SPOP_SBC_1	0.6218
p.P496H	TCGA-HU-A4GU	STAD	TCGA	VRTST	DEG_SPOP_SBC_1	0.2222
p.P496H	DO47849	STAD	ICGC	VRTST	DEG_SPOP_SBC_1	0.2222
p.T502A	DO222798	COCA	ICGC	VRTST	DEG_SPOP_SBC_1	0.7139
p.E490K	DO13863	GBM	ICGC	VRTST	DEG_SPOP_SBC_1	0.0556
p.E490K	DO228971	LICA	ICGC	VRTST	DEG_SPOP_SBC_1	0.0556
p.Q495K	DO229028	LICA	ICGC	VRTST	DEG_SPOP_SBC_1	0.1944
p.N500K	DO229006	LICA	ICGC	VRTST	DEG_SPOP_SBC_1	0.6918
p.Q499K	DO229009	LICA	ICGC	VRTST	DEG_SPOP_SBC_1	0.75
p.T502I	DO231712	LINC	ICGC	VRTST	DEG_SPOP_SBC_1	0.7078
p.E498Q	DO23742	LUAD	ICGC	VRTST	DEG_SPOP_SBC_1	0.2778
p.E503K	DO222843	MELA	ICGC	VRTST	DEG_SPOP_SBC_1	0.7022
p.E503G	DO229208	THCA	ICGC	VRTST	DEG_SPOP_SBC_1	0.7199
p.D494G	SIDM00217	Colorectal Carcinoma	GDSC	VRTST	DEG_SPOP_SBC_1	0.1667
p.D494G	ACH-000999	Colon/Colorectal Cancer	CCLE	VRTST	DEG_SPOP_SBC_1	0.1667
p.D494G	SNU-1040	large_intestine	COSMIC	VRTST	DEG_SPOP_SBC_1	0.1667
p.M506I	ACH-000495	Kidney Cancer	CCLE	VRTST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2TAC2	Coiled-coil domain-containing protein 57	DEG_SPOP_SBC_1	620:624	VRTST	SPOP	0.5097	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	144:148	VRTST	SPOP	0.9891	More...
Q9UK17	Potassium voltage-gated channel subfamily D member 3	DEG_SPOP_SBC_1	500:504	VRTST	SPOP	0.8401	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons