DegronMD - Q9UK17(KCND3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E509K	TCGA-19-5956	GBM	TCGA	VRTST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1944
p.E509K	TCGA-AG-A002	READ	TCGA	VRTST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1944
p.G637S	TCGA-23-2078	OV	TCGA	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.0833
p.E626K	TCGA-AP-A0LM	UCEC	TCGA	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation altering degron motif	0.591
p.E626K	TCGA-BH-A2L8	BRCA	TCGA	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation altering degron motif	0.591
p.E626K	TCGA-D6-A6ES	HNSC	TCGA	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation altering degron motif	0.591
p.L492I	TCGA-B5-A1MR	UCEC	TCGA	VRTST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1111
p.L492I	DO41758	UCEC	ICGC	VRTST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1111
p.A613V	TCGA-BF-A1PV	SKCM	TCGA	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.1111
p.I505M	TCGA-C8-A26X	BRCA	TCGA	VRTST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.3056
p.I505M	TCGA-DK-AA71	BLCA	TCGA	VRTST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.3056
p.I505M	DO219010	BLCA	ICGC	VRTST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.3056
p.I505M	DO5549	BRCA	ICGC	VRTST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.3056
p.A622V	TCGA-CG-4460	STAD	TCGA	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation altering degron motif	0.5825
p.P636R	TCGA-D3-A51E	SKCM	TCGA	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.1111
p.P636T	TCGA-D3-A51E	SKCM	TCGA	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.1111
p.R501Q	TCGA-DA-A1IC	SKCM	TCGA	VRTST	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.6218
p.R501Q	DO233764	GACA	ICGC	VRTST	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.6218
p.R501Q	DO37430	SKCM	ICGC	VRTST	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.6218
p.E626Q	TCGA-DK-A6B6	BLCA	TCGA	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation altering degron motif	0.5633
p.P496H	TCGA-HU-A4GU	STAD	TCGA	VRTST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2222
p.P496H	DO47849	STAD	ICGC	VRTST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2222
p.T502A	DO222798	COCA	ICGC	VRTST	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.7139
p.E490K	DO13863	GBM	ICGC	VRTST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0556
p.E490K	DO228971	LICA	ICGC	VRTST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0556
p.P624H	DO14766	HNSC	ICGC	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation altering degron motif	0.7694
p.Q495K	DO229028	LICA	ICGC	VRTST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1944
p.P624T	DO229038	LICA	ICGC	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation altering degron motif	0.7031
p.P614H	DO229038	LICA	ICGC	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.1389
p.N500K	DO229006	LICA	ICGC	VRTST	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.6918
p.Q499K	DO229009	LICA	ICGC	VRTST	DEG_SPOP_SBC_1	500:504	Mutation blocking phosphorylation signal	0.75
p.T502I	DO231712	LINC	ICGC	VRTST	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.7078
p.L636F	DO25847	LUAD	ICGC	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.1111
p.E498Q	DO23742	LUAD	ICGC	VRTST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2778
p.E503K	DO222843	MELA	ICGC	VRTST	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.7022
p.G618S	DO31829	OV	ICGC	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.25
p.S634C	DO36247	PRAD	ICGC	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.1667
p.P617T	DO47465	SKCM	ICGC	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.2222
p.P617R	DO47465	SKCM	ICGC	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.2222
p.E503G	DO229208	THCA	ICGC	VRTST	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.7199
p.S629R	SIDM00680	Colorectal Carcinoma	GDSC	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.3056
p.S629R	LS-180	large intestine	COSMIC	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.3056
p.D494G	SIDM00217	Colorectal Carcinoma	GDSC	VRTST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1667
p.D494G	ACH-000999	Colon/Colorectal Cancer	CCLE	VRTST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1667
p.D494G	SNU-1040	large intestine	COSMIC	VRTST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1667
p.R630Q	SIDM00150	Colorectal Carcinoma	GDSC	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.2778
p.R630Q	KM12	large intestine	COSMIC	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.2778
p.M506I	ACH-000495	Kidney Cancer	CCLE	VRTST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2778
p.A627T	ACH-000786	Lymphoma	CCLE	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation altering degron motif	0.7139
p.A635T	ACH-000922	Leukemia	CCLE	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.1389
p.A635T	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.1389
p.R611Q	ACH-000969	Colon/Colorectal Cancer	CCLE	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.0556
p.R611Q	KM12	large intestine	COSMIC	PALTPEGE	DEG_SCF_FBW7_2	621:628	Mutation rewiring degron network	0.0556

Kaplan plot for KCND3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCND3

UniProt ID: Q9UK17

Entrez ID: 3752

Protein name: Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCND3 in