DegronMD

Uniprot ID: Q9UK17

Source protein: Potassium voltage-gated channel subfamily D member 3

Source gene: KCND3

Class: DEG_SCF_FBW7_2

Location: 621:628

E3 ligase: FBXW7

DEGRON score: 0.9888

ASA_SCORE: 80.3875

COIL: 0.8885

CONS_SCORE: 0.3701

DSS_SCORE: 0.732

HELIX: 0.0445

FCONS_SCORE: 1.0894

RIG_SCORE: 0.6074

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G637S	TCGA-23-2078	OV	TCGA	PALTPEGE	DEG_SCF_FBW7_2	0.0833
p.E626K	TCGA-AP-A0LM	UCEC	TCGA	PALTPEGE	DEG_SCF_FBW7_2	0.591
p.E626K	TCGA-BH-A2L8	BRCA	TCGA	PALTPEGE	DEG_SCF_FBW7_2	0.591
p.E626K	TCGA-D6-A6ES	HNSC	TCGA	PALTPEGE	DEG_SCF_FBW7_2	0.591
p.A613V	TCGA-BF-A1PV	SKCM	TCGA	PALTPEGE	DEG_SCF_FBW7_2	0.1111
p.A622V	TCGA-CG-4460	STAD	TCGA	PALTPEGE	DEG_SCF_FBW7_2	0.5825
p.P636R	TCGA-D3-A51E	SKCM	TCGA	PALTPEGE	DEG_SCF_FBW7_2	0.1111
p.P636T	TCGA-D3-A51E	SKCM	TCGA	PALTPEGE	DEG_SCF_FBW7_2	0.1111
p.E626Q	TCGA-DK-A6B6	BLCA	TCGA	PALTPEGE	DEG_SCF_FBW7_2	0.5633
p.P624H	DO14766	HNSC	ICGC	PALTPEGE	DEG_SCF_FBW7_2	0.7694
p.P624T	DO229038	LICA	ICGC	PALTPEGE	DEG_SCF_FBW7_2	0.7031
p.P614H	DO229038	LICA	ICGC	PALTPEGE	DEG_SCF_FBW7_2	0.1389
p.L636F	DO25847	LUAD	ICGC	PALTPEGE	DEG_SCF_FBW7_2	0.1111
p.G618S	DO31829	OV	ICGC	PALTPEGE	DEG_SCF_FBW7_2	0.25
p.S634C	DO36247	PRAD	ICGC	PALTPEGE	DEG_SCF_FBW7_2	0.1667
p.P617T	DO47465	SKCM	ICGC	PALTPEGE	DEG_SCF_FBW7_2	0.2222
p.P617R	DO47465	SKCM	ICGC	PALTPEGE	DEG_SCF_FBW7_2	0.2222
p.S629R	SIDM00680	Colorectal Carcinoma	GDSC	PALTPEGE	DEG_SCF_FBW7_2	0.3056
p.S629R	LS-180	large_intestine	COSMIC	PALTPEGE	DEG_SCF_FBW7_2	0.3056
p.R630Q	SIDM00150	Colorectal Carcinoma	GDSC	PALTPEGE	DEG_SCF_FBW7_2	0.2778
p.R630Q	KM12	large_intestine	COSMIC	PALTPEGE	DEG_SCF_FBW7_2	0.2778
p.A627T	ACH-000786	Lymphoma	CCLE	PALTPEGE	DEG_SCF_FBW7_2	0.7139
p.A635T	ACH-000922	Leukemia	CCLE	PALTPEGE	DEG_SCF_FBW7_2	0.1389
p.A635T	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	PALTPEGE	DEG_SCF_FBW7_2	0.1389
p.R611Q	ACH-000969	Colon/Colorectal Cancer	CCLE	PALTPEGE	DEG_SCF_FBW7_2	0.0556
p.R611Q	KM12	large_intestine	COSMIC	PALTPEGE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UK17	Potassium voltage-gated channel subfamily D member 3	DEG_SCF_FBW7_2	621:628	PALTPEGE	FBXW7	0.9888	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PALTPEGE

Degron related mutations and impact score

Drug responses associated with KCND3 mutations

All proteins holding degron of PALTPEGE