DegronMD - Q2TAC2(CCDC57)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S619T	TCGA-A4-7828	KIRP	TCGA	VRTST	DEG_SPOP_SBC_1	620:624	Mutation rewiring degron network	0.3056
p.S619T	DO20760	KIRP	ICGC	VRTST	DEG_SPOP_SBC_1	620:624	Mutation rewiring degron network	0.3056
p.G634D	TCGA-CV-A6K2	HNSC	TCGA	VRTST	DEG_SPOP_SBC_1	620:624	Mutation rewiring degron network	0.0556
p.G634D	DO52079	HNSC	ICGC	VRTST	DEG_SPOP_SBC_1	620:624	Mutation rewiring degron network	0.0556
p.Q632K	TCGA-FS-A1Z4	SKCM	TCGA	VRTST	DEG_SPOP_SBC_1	620:624	Mutation rewiring degron network	0.1111
p.Q632K	DO37462	SKCM	ICGC	VRTST	DEG_SPOP_SBC_1	620:624	Mutation rewiring degron network	0.1111
p.S630Y	DO229045	LICA	ICGC	VRTST	DEG_SPOP_SBC_1	620:624	Mutation rewiring degron network	0.1667
p.S619I	DO232224	PBCA	ICGC	VRTST	DEG_SPOP_SBC_1	620:624	Mutation rewiring degron network	0.3056
p.R621C	DO229216	THCA	ICGC	VRTST	DEG_SPOP_SBC_1	620:624	Mutation altering degron motif	0.719
p.T626M	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VRTST	DEG_SPOP_SBC_1	620:624	Mutation rewiring degron network	0.2778
p.T626M	SIDM00203	Ewing's Sarcoma	GDSC	VRTST	DEG_SPOP_SBC_1	620:624	Mutation rewiring degron network	0.2778
p.V620G	SIDM01190	Bladder Carcinoma	GDSC	VRTST	DEG_SPOP_SBC_1	620:624	Mutation altering degron motif	0.7532
p.V620G	ACH-000720	Bladder Cancer	CCLE	VRTST	DEG_SPOP_SBC_1	620:624	Mutation altering degron motif	0.7532
p.V620G	TCCSUP	urinary tract	COSMIC	VRTST	DEG_SPOP_SBC_1	620:624	Mutation altering degron motif	0.7532

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons