DegronMD

Uniprot ID: Q9H4A3

Source protein: Serine/threonine-protein kinase WNK1

Source gene: WNK1

Class: DEG_SCF_TRCP1_1

Location: 656:662

E3 ligase: BTRC

DEGRON score: 0.9918

ASA_SCORE: 67.0429

COIL: 0.767

CONS_SCORE: 0.3741

DSS_SCORE: 0.5782

HELIX: 0.0604

FCONS_SCORE: 1.0783

RIG_SCORE: 0.6087

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S651F	TCGA-AP-A1DK	UCEC	TCGA	DSGQGSS	DEG_SCF_TRCP1_1	0.1944
p.S671I	TCGA-AX-A1CE	UCEC	TCGA	DSGQGSS	DEG_SCF_TRCP1_1	0.0833
p.S671I	TCGA-ZJ-AAX4	CESC	TCGA	DSGQGSS	DEG_SCF_TRCP1_1	0.0833
p.S671I	DO219750	CESC	ICGC	DSGQGSS	DEG_SCF_TRCP1_1	0.0833
p.S671I	DO42280	UCEC	ICGC	DSGQGSS	DEG_SCF_TRCP1_1	0.0833
p.R668Q	TCGA-N5-A4RF	UCS	TCGA	DSGQGSS	DEG_SCF_TRCP1_1	0.1667
p.T649P	DO229010	COCA	ICGC	DSGQGSS	DEG_SCF_TRCP1_1	0.1389
p.T649P	DO229013	COCA	ICGC	DSGQGSS	DEG_SCF_TRCP1_1	0.1389
p.T649P	DO229016	COCA	ICGC	DSGQGSS	DEG_SCF_TRCP1_1	0.1389
p.T649P	DO229003	COCA	ICGC	DSGQGSS	DEG_SCF_TRCP1_1	0.1389
p.T649P	DO229005	COCA	ICGC	DSGQGSS	DEG_SCF_TRCP1_1	0.1389
p.T649P	DO228947	LICA	ICGC	DSGQGSS	DEG_SCF_TRCP1_1	0.1389
p.T649P	DO231212	LUSC	ICGC	DSGQGSS	DEG_SCF_TRCP1_1	0.1389
p.P654L	DO14606	HNSC	ICGC	DSGQGSS	DEG_SCF_TRCP1_1	0.2778
p.A658T	DO27011	LUSC	ICGC	DSGQGSS	DEG_SCF_TRCP1_1	0.7139
p.R668L	SIDM01958	Esophageal Carcinoma	GDSC	DSGQGSS	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SCF_TRCP1_1	656:662	DSGQGSS	BTRC	0.9918	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons