DegronMD

Uniprot ID: Q9H4A3

Source protein: Serine/threonine-protein kinase WNK1

Source gene: WNK1

Class: DEG_SCF_FBW7_1

Location: 1734:1740

E3 ligase: FBXW7

DEGRON score: 0.8982

ASA_SCORE: 86.4429

COIL: 0.9294

CONS_SCORE: 0.3463

DSS_SCORE: 0.5468

HELIX: 0.0151

FCONS_SCORE: 0.9523

RIG_SCORE: 0.6868

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1734A	TCGA-A5-A0VP	UCEC	TCGA	VSTPVST	DEG_SCF_FBW7_1	0.6936
p.S1743L	TCGA-HU-A4GQ	STAD	TCGA	VSTPVST	DEG_SCF_FBW7_1	0.25
p.G1743A	DO11567	GBM	ICGC	VSTPVST	DEG_SCF_FBW7_1	0.25
p.P1739H	DO37438	SKCM	ICGC	VSTPVST	DEG_SCF_FBW7_1	0.7694
p.S1738N	DO41758	UCEC	ICGC	VSTPVST	DEG_SCF_FBW7_1	0.7069
p.V1737L	SIDM01503	Small Cell Lung Carcinoma	GDSC	VSTPVST	DEG_SCF_FBW7_1	0.6765
p.P1737A	SNU-387	liver	COSMIC	VSTPVST	DEG_SCF_FBW7_1	0.7503
p.S1740N	SW48	large_intestine	COSMIC	VSTPVST	DEG_SCF_FBW7_1	0.7069
p.V1735A	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	VSTPVST	DEG_SCF_FBW7_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SCF_FBW7_1	1734:1740	VSTPVST	FBXW7	0.8982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons