DegronMD

Uniprot ID: Q9H4A3

Source protein: Serine/threonine-protein kinase WNK1

Source gene: WNK1

Class: DEG_ODPH_VHL_1

Location: 960:971

E3 ligase: VHL

DEGRON score: 0.9817

ASA_SCORE: 79.5167

COIL: 0.8451

CONS_SCORE: 0.3783

DSS_SCORE: 0.3294

HELIX: 0.0602

FCONS_SCORE: 1.0395

RIG_SCORE: 0.7049

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P981S	TCGA-AP-A1DK	UCEC	TCGA	IAPSSNVASVCI	DEG_ODPH_VHL_1	0.0556
p.P979L	TCGA-EE-A2MJ	SKCM	TCGA	IAPSSNVASVCI	DEG_ODPH_VHL_1	0.1111
p.G975V	DO229019	LICA	ICGC	IAPSSNVASVCI	DEG_ODPH_VHL_1	0.2222
p.V979I	DO232224	PBCA	ICGC	IAPSSNVASVCI	DEG_ODPH_VHL_1	0.1111
p.S960P	DO41871	UCEC	ICGC	IAPSSNVASVCI	DEG_ODPH_VHL_1	0.6752
p.S977A	SIDM00845	Burkitt's Lymphoma	GDSC	IAPSSNVASVCI	DEG_ODPH_VHL_1	0.1667
p.S977A	SIDM00461	Acute Myeloid Leukemia	GDSC	IAPSSNVASVCI	DEG_ODPH_VHL_1	0.1667
p.S977A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	IAPSSNVASVCI	DEG_ODPH_VHL_1	0.1667
p.S977A	SIDM01519	Head and Neck Carcinoma	GDSC	IAPSSNVASVCI	DEG_ODPH_VHL_1	0.1667
p.G956E	ACH-000279	Bone Cancer	CCLE	IAPSSNVASVCI	DEG_ODPH_VHL_1	0.2222
p.D966Y	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	IAPSSNVASVCI	DEG_ODPH_VHL_1	0.7325
p.L976F	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	IAPSSNVASVCI	DEG_ODPH_VHL_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_ODPH_VHL_1	960:971	IAPSSNVASVCI	VHL	0.9817	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons