DegronMD

Uniprot ID: Q9H4A3

Source protein: Serine/threonine-protein kinase WNK1

Source gene: WNK1

Class: DEG_SCF_FBW7_1

Location: 1723:1730

E3 ligase: FBXW7

DEGRON score: 0.9196

ASA_SCORE: 90.525

COIL: 0.9543

CONS_SCORE: 0.3274

DSS_SCORE: 0.3985

HELIX: 0.0074

FCONS_SCORE: 0.9005

RIG_SCORE: 0.7888

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1728F	DO43755	UCEC	ICGC	LPVTPVVT	DEG_SCF_FBW7_1	0.7982
p.V1727A	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LPVTPVVT	DEG_SCF_FBW7_1	0.6936
p.V1727A	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LPVTPVVT	DEG_SCF_FBW7_1	0.6936
p.V1727A	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LPVTPVVT	DEG_SCF_FBW7_1	0.6936
p.A1722V	ACH-000961	Endometrial/Uterine Cancer	CCLE	LPVTPVVT	DEG_SCF_FBW7_1	0.3056
p.S1713F	COLO-679	skin	COSMIC	LPVTPVVT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SCF_FBW7_1	1723:1730	LPVTPVVT	FBXW7	0.9196	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons