DegronMD

Uniprot ID: Q9H4A3

Source protein: Serine/threonine-protein kinase WNK1

Source gene: WNK1

Class: DEG_SPOP_SBC_1

Location: 1480:1484

E3 ligase: SPOP

DEGRON score: 0.9785

ASA_SCORE: 77.88

COIL: 0.8784

CONS_SCORE: 0.3557

DSS_SCORE: 0.3997

HELIX: 0.0346

FCONS_SCORE: 1.0269

RIG_SCORE: 0.6676

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1491L	TCGA-A8-A0A7	BRCA	TCGA	AGSTT	DEG_SPOP_SBC_1	0.1389
p.L1489I	TCGA-B5-A0JU	UCEC	TCGA	AGSTT	DEG_SPOP_SBC_1	0.1944
p.S1476Y	TCGA-B5-A0JY	UCEC	TCGA	AGSTT	DEG_SPOP_SBC_1	0.2222
p.S1476F	TCGA-D3-A3MV	SKCM	TCGA	AGSTT	DEG_SPOP_SBC_1	0.2222
p.P1471L	TCGA-DU-8158	LGG	TCGA	AGSTT	DEG_SPOP_SBC_1	0.0833
p.S1482N	TCGA-EO-A22U	UCEC	TCGA	AGSTT	DEG_SPOP_SBC_1	0.7069
p.A1480T	TCGA-G4-6588	COAD	TCGA	AGSTT	DEG_SPOP_SBC_1	0.7139
p.E1471D	DO1285	BRCA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.0833
p.S1491I	DO228986	LICA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.1389
p.S1475F	DO38871	STAD	ICGC	AGSTT	DEG_SPOP_SBC_1	0.1944
p.L1475F	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.1944
p.L1475F	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1944
p.S1472Y	SIDM01611	Endometrial Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.1111
p.V1485L	ACH-000844	Lung Cancer	CCLE	AGSTT	DEG_SPOP_SBC_1	0.3056
p.V1475A	ACH-000995	Leukemia	CCLE	AGSTT	DEG_SPOP_SBC_1	0.1944
p.V1475A	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1944
p.A1480S	ACH-002800	Unknown	CCLE	AGSTT	DEG_SPOP_SBC_1	0.7588
p.P1474Q	SK-OV-3	ovary	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1667
p.P1490A	SNU-387	liver	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1667
p.D1473Y	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1389
p.L1483F	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.6981
p.T1476I	OCI-AML2	haematopoietic_and_lymphoid_tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.2222
p.D1487Y	SK-MG-1	central_nervous_system	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52951	Homeobox protein GBX-2	DEG_SPOP_SBC_1	238:242	AGSTT	SPOP	0.9792	More...
Q6WN34	Chordin-like protein 2	DEG_SPOP_SBC_1	235:239	AGSTT	SPOP	0.9287	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	491:495	AGSTT	SPOP	0.9844	More...
Q9BQF6	Sentrin-specific protease 7	DEG_SPOP_SBC_1	387:391	AGSTT	SPOP	0.9925	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1480:1484	AGSTT	SPOP	0.9785	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	765:769	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1820:1824	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3377:3381	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4460:4464	AGSTT	SPOP	0.9616	More...
Q9UPV0	Centrosomal protein of 164 kDa	DEG_SPOP_SBC_1	1404:1408	AGSTT	SPOP	0.8025	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons