DegronMD

Uniprot ID: Q6WN34

Source protein: Chordin-like protein 2

Source gene: CHRDL2

Class: DEG_SPOP_SBC_1

Location: 235:239

E3 ligase: SPOP

DEGRON score: 0.9287

ASA_SCORE: 62.62

COIL: 0.7882

CONS_SCORE: 0.4835

DSS_SCORE: 0.4795

HELIX: 0.036

FCONS_SCORE: 1.0309

RIG_SCORE: 0.6788

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G236C	TCGA-92-7340	LUSC	TCGA	AGSTT	DEG_SPOP_SBC_1	0.6489
p.G236C	DO26775	LUSC	ICGC	AGSTT	DEG_SPOP_SBC_1	0.6489
p.G234R	TCGA-DX-A8BP	SARC	TCGA	AGSTT	DEG_SPOP_SBC_1	0.3056
p.G234R	DO220056	SARC	ICGC	AGSTT	DEG_SPOP_SBC_1	0.3056
p.K233N	TCGA-EE-A20F	SKCM	TCGA	AGSTT	DEG_SPOP_SBC_1	0.2778
p.K233N	DO37961	SKCM	ICGC	AGSTT	DEG_SPOP_SBC_1	0.2778
p.K249E	TCGA-FR-A7U9	SKCM	TCGA	AGSTT	DEG_SPOP_SBC_1	0.1667
p.K249E	DO48546	SKCM	ICGC	AGSTT	DEG_SPOP_SBC_1	0.1667
p.R231K	DO231027	LUSC	ICGC	AGSTT	DEG_SPOP_SBC_1	0.2222
p.P232L	DO222653	MELA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.25
p.I226T	SIDM00545	Melanoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.0833
p.I226T	ACH-000987	Skin Cancer	CCLE	AGSTT	DEG_SPOP_SBC_1	0.0833
p.I226T	Mewo	skin	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.0833
p.I226V	SIDM00773	Non-Cancerous	GDSC	AGSTT	DEG_SPOP_SBC_1	0.0833
p.I226V	SIDM01090	Colorectal Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.0833
p.I226V	SIDM00210	Ovarian Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.0833
p.I226V	SIDM00529	Breast Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.0833
p.I226V	SIDM00971	Breast Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.0833
p.I226V	SIDM00493	Other Solid Cancers	GDSC	AGSTT	DEG_SPOP_SBC_1	0.0833
p.I226V	SIDM00875	Breast Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.0833
p.I226V	SIDM00309	Mesothelioma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.0833
p.I226V	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.0833
p.I226V	SIDM00774	Breast Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.0833
p.I226V	SIDM00257	Neuroblastoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.0833
p.I226V	SIDM00760	Small Cell Lung Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52951	Homeobox protein GBX-2	DEG_SPOP_SBC_1	238:242	AGSTT	SPOP	0.9792	More...
Q6WN34	Chordin-like protein 2	DEG_SPOP_SBC_1	235:239	AGSTT	SPOP	0.9287	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	491:495	AGSTT	SPOP	0.9844	More...
Q9BQF6	Sentrin-specific protease 7	DEG_SPOP_SBC_1	387:391	AGSTT	SPOP	0.9925	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1480:1484	AGSTT	SPOP	0.9785	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	765:769	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1820:1824	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3377:3381	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4460:4464	AGSTT	SPOP	0.9616	More...
Q9UPV0	Centrosomal protein of 164 kDa	DEG_SPOP_SBC_1	1404:1408	AGSTT	SPOP	0.8025	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons