DegronMD

Uniprot ID: Q9UKN1

Source protein: Mucin-12

Source gene: MUC12

Class: DEG_SPOP_SBC_1

Location: 3377:3381

E3 ligase: SPOP

DEGRON score: 0.9616

ASA_SCORE: 73.76

COIL: 0.8432

CONS_SCORE: 0

DSS_SCORE: 0.7389

HELIX: 0.0206

FCONS_SCORE: 0

RIG_SCORE: 0.583

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H3371R	DO229042	LICA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.1667
p.H3371R	DO46771	PAEN	ICGC	AGSTT	DEG_SPOP_SBC_1	0.1667
p.G3378S	DO229051	LICA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.5882
p.T3387A	HOS	bone	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1667
p.T3387A	EW-1	bone	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1667
p.T3387A	NUGC-4	stomach	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1667
p.T3387A	CADO-ES1	bone	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1667
p.T3387A	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1667
p.H3371Q	DMS-79	lung	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1667
p.P3376H	SK-MEL-2	skin	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.3056
p.G3384R	Mewo	skin	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.25
p.R3382C	HUTU-80	small_intestine	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.3056
p.R3382C	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.3056
p.R3382C	NCI-H2081	lung	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.3056
p.S3369L	H2373	pleura	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1111
p.S3369L	AU565	breast	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1111
p.S3369L	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1111
p.S3369L	MPP-89	pleura	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1111
p.S3369L	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1111
p.G3368A	NCI-H292	lung	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.0833
p.T3380A	NCI-H2172	lung	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.7139
p.S3375P	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.7222
p.A3377D	H3255	lung	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.7793

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52951	Homeobox protein GBX-2	DEG_SPOP_SBC_1	238:242	AGSTT	SPOP	0.9792	More...
Q6WN34	Chordin-like protein 2	DEG_SPOP_SBC_1	235:239	AGSTT	SPOP	0.9287	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	491:495	AGSTT	SPOP	0.9844	More...
Q9BQF6	Sentrin-specific protease 7	DEG_SPOP_SBC_1	387:391	AGSTT	SPOP	0.9925	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1480:1484	AGSTT	SPOP	0.9785	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	765:769	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1820:1824	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3377:3381	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4460:4464	AGSTT	SPOP	0.9616	More...
Q9UPV0	Centrosomal protein of 164 kDa	DEG_SPOP_SBC_1	1404:1408	AGSTT	SPOP	0.8025	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons