DegronMD

Uniprot ID: Q9UKN1

Source protein: Mucin-12

Source gene: MUC12

Class: DEG_SPOP_SBC_1

Location: 4460:4464

E3 ligase: SPOP

DEGRON score: 0.9616

ASA_SCORE: 72.52

COIL: 0.8644

CONS_SCORE: 0

DSS_SCORE: 0.7389

HELIX: 0.0234

FCONS_SCORE: 0

RIG_SCORE: 0.583

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T4470I	DO229016	COCA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.1667
p.T4470I	DO229048	LICA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.1667
p.T4463I	DO228943	LICA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.7078
p.R4465L	DO229037	LICA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.3056
p.S4452L	DO220903	MELA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.1111
p.T4454P	SIDM02054	Esophageal Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.1667
p.L4457M	ACH-000900	Lung Cancer	CCLE	AGSTT	DEG_SPOP_SBC_1	0.25
p.R4465H	EW-11	bone	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.3056
p.R4465H	HCC-15	lung	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.3056
p.R4465H	COLO-680N	oesophagus	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.3056
p.R4465H	MDA-MB-361	breast	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.3056
p.F4472L	NCI-H1694	lung	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1111
p.T4464S	COLO-684	endometrium	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.6005
p.Q4466E	HCC-15	lung	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.2778
p.Q4466E	COLO-680N	oesophagus	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.2778
p.G4467E	Mewo	skin	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.25
p.G4461S	KYSE-510	oesophagus	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.5882
p.A4460S	SK-MEL-1	skin	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.7588
p.S4474R	NCI-H1573	lung	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52951	Homeobox protein GBX-2	DEG_SPOP_SBC_1	238:242	AGSTT	SPOP	0.9792	More...
Q6WN34	Chordin-like protein 2	DEG_SPOP_SBC_1	235:239	AGSTT	SPOP	0.9287	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	491:495	AGSTT	SPOP	0.9844	More...
Q9BQF6	Sentrin-specific protease 7	DEG_SPOP_SBC_1	387:391	AGSTT	SPOP	0.9925	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1480:1484	AGSTT	SPOP	0.9785	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	765:769	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1820:1824	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3377:3381	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4460:4464	AGSTT	SPOP	0.9616	More...
Q9UPV0	Centrosomal protein of 164 kDa	DEG_SPOP_SBC_1	1404:1408	AGSTT	SPOP	0.8025	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons