DegronMD

Uniprot ID: Q6ZSZ6

Source protein: Teashirt homolog 1

Source gene: TSHZ1

Class: DEG_SPOP_SBC_1

Location: 491:495

E3 ligase: SPOP

DEGRON score: 0.9844

ASA_SCORE: 75.7

COIL: 0.9084

CONS_SCORE: 0.3939

DSS_SCORE: 0.7922

HELIX: 0.0368

FCONS_SCORE: 0.9842

RIG_SCORE: 0.4947

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G503V	TCGA-37-A5EN	LUSC	TCGA	AGSTT	DEG_SPOP_SBC_1	0.1111
p.K501N	TCGA-44-6778	LUAD	TCGA	AGSTT	DEG_SPOP_SBC_1	0.1667
p.K501N	TCGA-64-5779	LUAD	TCGA	AGSTT	DEG_SPOP_SBC_1	0.1667
p.D497Y	TCGA-49-AAR9	LUAD	TCGA	AGSTT	DEG_SPOP_SBC_1	0.2778
p.S485I	TCGA-A5-A0G2	UCEC	TCGA	AGSTT	DEG_SPOP_SBC_1	0.2778
p.P484T	TCGA-BG-A222	UCEC	TCGA	AGSTT	DEG_SPOP_SBC_1	0.25
p.E494D	TCGA-DF-A2KN	UCEC	TCGA	AGSTT	DEG_SPOP_SBC_1	0.6758
p.E494D	LS-180	large_intestine	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.6758
p.P489L	TCGA-DF-A2KU	UCEC	TCGA	AGSTT	DEG_SPOP_SBC_1	0.7222
p.T494M	DO222755	COCA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.7423
p.G492V	DO26590	LUSC	ICGC	AGSTT	DEG_SPOP_SBC_1	0.6421
p.S481F	DO222632	MELA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.0556
p.S482G	DO48173	UCEC	ICGC	AGSTT	DEG_SPOP_SBC_1	0.5278
p.S489C	SIDM00443	B-Cell Non-Hodgkin's Lymphoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.7222
p.S489C	ACH-000287	Lymphoma	CCLE	AGSTT	DEG_SPOP_SBC_1	0.7222
p.S489C	NU-DUL-1	haematopoietic_and_lymphoid_tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.7222
p.Y490F	MCC13	skin	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.3056
p.P500R	SW1271	lung	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52951	Homeobox protein GBX-2	DEG_SPOP_SBC_1	238:242	AGSTT	SPOP	0.9792	More...
Q6WN34	Chordin-like protein 2	DEG_SPOP_SBC_1	235:239	AGSTT	SPOP	0.9287	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	491:495	AGSTT	SPOP	0.9844	More...
Q9BQF6	Sentrin-specific protease 7	DEG_SPOP_SBC_1	387:391	AGSTT	SPOP	0.9925	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1480:1484	AGSTT	SPOP	0.9785	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	765:769	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1820:1824	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3377:3381	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4460:4464	AGSTT	SPOP	0.9616	More...
Q9UPV0	Centrosomal protein of 164 kDa	DEG_SPOP_SBC_1	1404:1408	AGSTT	SPOP	0.8025	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons