DegronMD

Uniprot ID: Q9BQF6

Source protein: Sentrin-specific protease 7

Source gene: SENP7

Class: DEG_SPOP_SBC_1

Location: 387:391

E3 ligase: SPOP

DEGRON score: 0.9925

ASA_SCORE: 76.54

COIL: 0.9306

CONS_SCORE: 0.2752

DSS_SCORE: 0.5223

HELIX: 0.0336

FCONS_SCORE: 0.9678

RIG_SCORE: 0.6251

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G388S	TCGA-BR-8487	STAD	TCGA	AGSTT	DEG_SPOP_SBC_1	0.5882
p.L378F	TCGA-BT-A20P	BLCA	TCGA	AGSTT	DEG_SPOP_SBC_1	0.0833
p.T382I	TCGA-QB-AA9O	SKCM	TCGA	AGSTT	DEG_SPOP_SBC_1	0.1944
p.T390A	TCGA-XF-A9T5	BLCA	TCGA	AGSTT	DEG_SPOP_SBC_1	0.7139
p.A385D	TCGA-XK-AAIW	PRAD	TCGA	AGSTT	DEG_SPOP_SBC_1	0.2778
p.K381N	DO228864	LICA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.1667
p.D399Y	DO45456	LUSC	ICGC	AGSTT	DEG_SPOP_SBC_1	0.1111
p.P386S	DO41235	UCEC	ICGC	AGSTT	DEG_SPOP_SBC_1	0.3056
p.E395G	SIDM00931	Thyroid Gland Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.2222
p.E395G	ACH-000174	Thyroid Cancer	CCLE	AGSTT	DEG_SPOP_SBC_1	0.2222
p.E395G	CAL-62	thyroid	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.2222
p.S386C	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.3056
p.S386C	ACH-002253	Lymphoma	CCLE	AGSTT	DEG_SPOP_SBC_1	0.3056
p.S386C	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.3056
p.E392K	ACH-001518	Endometrial/Uterine Cancer	CCLE	AGSTT	DEG_SPOP_SBC_1	0.3056
p.K393N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.2778
p.L391M	TOV-21G	ovary	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.711
p.S397F	NCI-H1770	lung	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1667
p.K394N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.25
p.S396F	NCI-H1770	lung	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52951	Homeobox protein GBX-2	DEG_SPOP_SBC_1	238:242	AGSTT	SPOP	0.9792	More...
Q6WN34	Chordin-like protein 2	DEG_SPOP_SBC_1	235:239	AGSTT	SPOP	0.9287	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	491:495	AGSTT	SPOP	0.9844	More...
Q9BQF6	Sentrin-specific protease 7	DEG_SPOP_SBC_1	387:391	AGSTT	SPOP	0.9925	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1480:1484	AGSTT	SPOP	0.9785	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	765:769	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1820:1824	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3377:3381	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4460:4464	AGSTT	SPOP	0.9616	More...
Q9UPV0	Centrosomal protein of 164 kDa	DEG_SPOP_SBC_1	1404:1408	AGSTT	SPOP	0.8025	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons