DegronMD - Q9BQF6(SENP7)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G388S	TCGA-BR-8487	STAD	TCGA	AGSTT	DEG_SPOP_SBC_1	387:391	Mutation altering degron motif	0.5882
p.L378F	TCGA-BT-A20P	BLCA	TCGA	AGSTT	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.0833
p.D194N	TCGA-CM-6678	COAD	TCGA	IRTPPVT	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.1111
p.D194N	DO10220	COAD	ICGC	IRTPPVT	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.1111
p.P183L	TCGA-FW-A3R5	SKCM	TCGA	IRTPPVT	DEG_SCF_FBW7_1	180:186	Mutation altering degron motif	0.7582
p.P183L	DO37406	SKCM	ICGC	IRTPPVT	DEG_SCF_FBW7_1	180:186	Mutation altering degron motif	0.7582
p.T382I	TCGA-QB-AA9O	SKCM	TCGA	AGSTT	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.1944
p.T390A	TCGA-XF-A9T5	BLCA	TCGA	AGSTT	DEG_SPOP_SBC_1	387:391	Mutation altering degron motif	0.7139
p.A385D	TCGA-XK-AAIW	PRAD	TCGA	AGSTT	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.2778
p.T194S	DO225065	BRCA	ICGC	IRTPPVT	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.1111
p.K381N	DO228864	LICA	ICGC	AGSTT	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.1667
p.L188M	DO229028	LICA	ICGC	IRTPPVT	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.2778
p.T173K	DO229037	LICA	ICGC	IRTPPVT	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.1389
p.T173M	DO229270	LMS	ICGC	IRTPPVT	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.1389
p.D399Y	DO45456	LUSC	ICGC	AGSTT	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.1111
p.E190A	DO232761	PBCA	ICGC	IRTPPVT	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.2222
p.P386S	DO41235	UCEC	ICGC	AGSTT	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.3056
p.P189S	DO41361	UCEC	ICGC	IRTPPVT	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.25
p.E187D	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	IRTPPVT	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.3056
p.E187D	ACH-000718	Lung Cancer	CCLE	IRTPPVT	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.3056
p.E187D	NCI-H2291	lung	COSMIC	IRTPPVT	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.3056
p.E395G	SIDM00931	Thyroid Gland Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.2222
p.E395G	ACH-000174	Thyroid Cancer	CCLE	AGSTT	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.2222
p.E395G	CAL-62	thyroid	COSMIC	AGSTT	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.2222
p.S386C	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	AGSTT	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.3056
p.S386C	ACH-002253	Lymphoma	CCLE	AGSTT	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.3056
p.S386C	JSC-1	haematopoietic and lymphoid tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.3056
p.E392K	ACH-001518	Endometrial/Uterine Cancer	CCLE	AGSTT	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.3056
p.K185N	S-117	soft tissue	COSMIC	IRTPPVT	DEG_SCF_FBW7_1	180:186	Mutation altering degron motif	0.6918
p.Q175K	TE-4	oesophagus	COSMIC	IRTPPVT	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.1944
p.K186N	S-117	soft tissue	COSMIC	IRTPPVT	DEG_SCF_FBW7_1	180:186	Mutation altering degron motif	0.6918
p.E182K	BC-3	haematopoietic and lymphoid tissue	COSMIC	IRTPPVT	DEG_SCF_FBW7_1	180:186	Mutation altering degron motif	0.7022
p.K180I	NCI-H1688	lung	COSMIC	IRTPPVT	DEG_SCF_FBW7_1	180:186	Mutation altering degron motif	0.7531
p.K181I	NCI-H1688	lung	COSMIC	IRTPPVT	DEG_SCF_FBW7_1	180:186	Mutation altering degron motif	0.7531
p.K393N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.2778
p.T170P	TGBC11TKB	stomach	COSMIC	IRTPPVT	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.0556
p.L391M	TOV-21G	ovary	COSMIC	AGSTT	DEG_SPOP_SBC_1	387:391	Mutation altering degron motif	0.711
p.S397F	NCI-H1770	lung	COSMIC	AGSTT	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.1667
p.S195L	NCI-H1944	lung	COSMIC	IRTPPVT	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.0833
p.K394N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.25
p.Q176K	TE-4	oesophagus	COSMIC	IRTPPVT	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.2222
p.S396F	NCI-H1770	lung	COSMIC	AGSTT	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.1944
p.E181K	BC-3	haematopoietic and lymphoid tissue	COSMIC	IRTPPVT	DEG_SCF_FBW7_1	180:186	Mutation altering degron motif	0.7022

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SENP7

UniProt ID: Q9BQF6

Entrez ID: 57337

Protein name: Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SENP7 in