DegronMD

Uniprot ID: Q9BQF6

Source protein: Sentrin-specific protease 7

Source gene: SENP7

Class: DEG_SCF_FBW7_1

Location: 180:186

E3 ligase: FBXW7

DEGRON score: 0.6669

ASA_SCORE: 91.0571

COIL: 0.8466

CONS_SCORE: 0.2934

DSS_SCORE: 0.4876

HELIX: 0.022

FCONS_SCORE: 0.9883

RIG_SCORE: 0.7507

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D194N	TCGA-CM-6678	COAD	TCGA	IRTPPVT	DEG_SCF_FBW7_1	0.1111
p.D194N	DO10220	COAD	ICGC	IRTPPVT	DEG_SCF_FBW7_1	0.1111
p.P183L	TCGA-FW-A3R5	SKCM	TCGA	IRTPPVT	DEG_SCF_FBW7_1	0.7582
p.P183L	DO37406	SKCM	ICGC	IRTPPVT	DEG_SCF_FBW7_1	0.7582
p.T194S	DO225065	BRCA	ICGC	IRTPPVT	DEG_SCF_FBW7_1	0.1111
p.L188M	DO229028	LICA	ICGC	IRTPPVT	DEG_SCF_FBW7_1	0.2778
p.T173K	DO229037	LICA	ICGC	IRTPPVT	DEG_SCF_FBW7_1	0.1389
p.T173M	DO229270	LMS	ICGC	IRTPPVT	DEG_SCF_FBW7_1	0.1389
p.E190A	DO232761	PBCA	ICGC	IRTPPVT	DEG_SCF_FBW7_1	0.2222
p.P189S	DO41361	UCEC	ICGC	IRTPPVT	DEG_SCF_FBW7_1	0.25
p.E187D	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	IRTPPVT	DEG_SCF_FBW7_1	0.3056
p.E187D	ACH-000718	Lung Cancer	CCLE	IRTPPVT	DEG_SCF_FBW7_1	0.3056
p.E187D	NCI-H2291	lung	COSMIC	IRTPPVT	DEG_SCF_FBW7_1	0.3056
p.K185N	S-117	soft_tissue	COSMIC	IRTPPVT	DEG_SCF_FBW7_1	0.6918
p.Q175K	TE-4	oesophagus	COSMIC	IRTPPVT	DEG_SCF_FBW7_1	0.1944
p.K186N	S-117	soft_tissue	COSMIC	IRTPPVT	DEG_SCF_FBW7_1	0.6918
p.E182K	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	IRTPPVT	DEG_SCF_FBW7_1	0.7022
p.K180I	NCI-H1688	lung	COSMIC	IRTPPVT	DEG_SCF_FBW7_1	0.7531
p.K181I	NCI-H1688	lung	COSMIC	IRTPPVT	DEG_SCF_FBW7_1	0.7531
p.T170P	TGBC11TKB	stomach	COSMIC	IRTPPVT	DEG_SCF_FBW7_1	0.0556
p.S195L	NCI-H1944	lung	COSMIC	IRTPPVT	DEG_SCF_FBW7_1	0.0833
p.Q176K	TE-4	oesophagus	COSMIC	IRTPPVT	DEG_SCF_FBW7_1	0.2222
p.E181K	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	IRTPPVT	DEG_SCF_FBW7_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQF6	Sentrin-specific protease 7	DEG_SCF_FBW7_1	180:186	IRTPPVT	FBXW7	0.6669	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons