DegronMD - Q6WN34(CHRDL2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G236C	TCGA-92-7340	LUSC	TCGA	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation altering degron motif	0.6489
p.G236C	DO26775	LUSC	ICGC	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation altering degron motif	0.6489
p.S224N	TCGA-CA-6718	COAD	TCGA	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.1389
p.S224N	DO7801	COAD	ICGC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.1389
p.P211L	TCGA-DG-A2KJ	CESC	TCGA	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation altering degron motif	0.6471
p.P211L	TCGA-XK-AAIW	PRAD	TCGA	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation altering degron motif	0.6471
p.P211L	DO51594	CESC	ICGC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation altering degron motif	0.6471
p.P211L	DO8858	COAD	ICGC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation altering degron motif	0.6471
p.P211L	DO51407	PRAD	ICGC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation altering degron motif	0.6471
p.P211L	SIDM01729	Endometrial Carcinoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation altering degron motif	0.6471
p.P211L	ACH-000909	Endometrial/Uterine Cancer	CCLE	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation altering degron motif	0.6471
p.K208N	TCGA-DK-A3WX	BLCA	TCGA	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation substituting flanking lysine	0.3611
p.K208N	DO696	BLCA	ICGC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation substituting flanking lysine	0.3611
p.S203N	TCGA-DU-6407	LGG	TCGA	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.1111
p.S203N	DO22295	LGG	ICGC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.1111
p.G234R	TCGA-DX-A8BP	SARC	TCGA	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.3056
p.G234R	DO220056	SARC	ICGC	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.3056
p.K233N	TCGA-EE-A20F	SKCM	TCGA	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.2778
p.K233N	DO37961	SKCM	ICGC	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.2778
p.K249E	TCGA-FR-A7U9	SKCM	TCGA	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation substituting flanking lysine	0.1667
p.K249E	DO48546	SKCM	ICGC	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation substituting flanking lysine	0.1667
p.G206E	TCGA-IH-A3EA	SKCM	TCGA	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.1944
p.G206E	DO37667	SKCM	ICGC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.1944
p.A221T	TCGA-L5-A43J	ESCA	TCGA	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.2222
p.A221T	DO227646	COCA	ICGC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.2222
p.A221T	ACH-001991	Primary	CCLE	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.2222
p.S203G	TCGA-VQ-A8PX	STAD	TCGA	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.1111
p.S203G	DO51778	STAD	ICGC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.1111
p.R209I	DO233156	GACA	ICGC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.2778
p.S220R	DO228952	LICA	ICGC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.25
p.R231K	DO231027	LUSC	ICGC	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.2222
p.P232L	DO222653	MELA	ICGC	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.25
p.A215V	DO222708	MELA	ICGC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation altering degron motif	0.5825
p.I226T	SIDM00545	Melanoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.0833
p.I226T	SIDM00545	Melanoma	GDSC	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.0833
p.I226T	ACH-000987	Skin Cancer	CCLE	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.0833
p.I226T	ACH-000987	Skin Cancer	CCLE	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.0833
p.I226T	Mewo	skin	COSMIC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.0833
p.I226T	Mewo	skin	COSMIC	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.0833
p.I226V	SIDM00773	Non-Cancerous	GDSC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.0833
p.I226V	SIDM00773	Non-Cancerous	GDSC	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.0833
p.I226V	SIDM01090	Colorectal Carcinoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.0833
p.I226V	SIDM01090	Colorectal Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.0833
p.I226V	SIDM00210	Ovarian Carcinoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.0833
p.I226V	SIDM00210	Ovarian Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.0833
p.I226V	SIDM00529	Breast Carcinoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.0833
p.I226V	SIDM00529	Breast Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.0833
p.I226V	SIDM00971	Breast Carcinoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.0833
p.I226V	SIDM00971	Breast Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.0833
p.I226V	SIDM00493	Other Solid Cancers	GDSC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.0833
p.I226V	SIDM00493	Other Solid Cancers	GDSC	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.0833
p.I226V	SIDM00875	Breast Carcinoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.0833
p.I226V	SIDM00875	Breast Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.0833
p.I226V	SIDM00309	Mesothelioma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.0833
p.I226V	SIDM00309	Mesothelioma	GDSC	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.0833
p.I226V	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.0833
p.I226V	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.0833
p.I226V	SIDM00774	Breast Carcinoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.0833
p.I226V	SIDM00774	Breast Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.0833
p.I226V	SIDM00257	Neuroblastoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.0833
p.I226V	SIDM00257	Neuroblastoma	GDSC	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.0833
p.I226V	SIDM00760	Small Cell Lung Carcinoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.0833
p.I226V	SIDM00760	Small Cell Lung Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.0833
p.S220N	SIDM00487	Colorectal Carcinoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.25
p.S220N	ACH-000963	Colon/Colorectal Cancer	CCLE	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.25
p.S220N	CCK-81	large intestine	COSMIC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.25
p.R207I	SIDM01662	Plasma Cell Myeloma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.2222
p.R207I	ACH-000564	Myeloma	CCLE	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation rewiring degron network	0.2222
p.S213G	22RV1	prostate	COSMIC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation altering degron motif	0.6993
p.G212S	NCCIT	testis	COSMIC	PGTPAPT	DEG_SCF_FBW7_1	211:217	Mutation altering degron motif	0.5882

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHRDL2

UniProt ID: Q6WN34

Entrez ID: 25884

Protein name: Chordin-like protein 2 (Breast tumor novel factor 1) (BNF-1) (Chordin-related protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHRDL2 in