DegronMD

Uniprot ID: Q6WN34

Source protein: Chordin-like protein 2

Source gene: CHRDL2

Class: DEG_SCF_FBW7_1

Location: 211:217

E3 ligase: FBXW7

DEGRON score: 0.8325

ASA_SCORE: 68.9143

COIL: 0.8074

CONS_SCORE: 0.3984

DSS_SCORE: 0.6759

HELIX: 0.026

FCONS_SCORE: 0.9543

RIG_SCORE: 0.5633

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S224N	TCGA-CA-6718	COAD	TCGA	PGTPAPT	DEG_SCF_FBW7_1	0.1389
p.S224N	DO7801	COAD	ICGC	PGTPAPT	DEG_SCF_FBW7_1	0.1389
p.P211L	TCGA-DG-A2KJ	CESC	TCGA	PGTPAPT	DEG_SCF_FBW7_1	0.6471
p.P211L	TCGA-XK-AAIW	PRAD	TCGA	PGTPAPT	DEG_SCF_FBW7_1	0.6471
p.P211L	DO51594	CESC	ICGC	PGTPAPT	DEG_SCF_FBW7_1	0.6471
p.P211L	DO8858	COAD	ICGC	PGTPAPT	DEG_SCF_FBW7_1	0.6471
p.P211L	DO51407	PRAD	ICGC	PGTPAPT	DEG_SCF_FBW7_1	0.6471
p.P211L	SIDM01729	Endometrial Carcinoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	0.6471
p.P211L	ACH-000909	Endometrial/Uterine Cancer	CCLE	PGTPAPT	DEG_SCF_FBW7_1	0.6471
p.K208N	TCGA-DK-A3WX	BLCA	TCGA	PGTPAPT	DEG_SCF_FBW7_1	0.3611
p.K208N	DO696	BLCA	ICGC	PGTPAPT	DEG_SCF_FBW7_1	0.3611
p.S203N	TCGA-DU-6407	LGG	TCGA	PGTPAPT	DEG_SCF_FBW7_1	0.1111
p.S203N	DO22295	LGG	ICGC	PGTPAPT	DEG_SCF_FBW7_1	0.1111
p.G206E	TCGA-IH-A3EA	SKCM	TCGA	PGTPAPT	DEG_SCF_FBW7_1	0.1944
p.G206E	DO37667	SKCM	ICGC	PGTPAPT	DEG_SCF_FBW7_1	0.1944
p.A221T	TCGA-L5-A43J	ESCA	TCGA	PGTPAPT	DEG_SCF_FBW7_1	0.2222
p.A221T	DO227646	COCA	ICGC	PGTPAPT	DEG_SCF_FBW7_1	0.2222
p.A221T	ACH-001991	Primary	CCLE	PGTPAPT	DEG_SCF_FBW7_1	0.2222
p.S203G	TCGA-VQ-A8PX	STAD	TCGA	PGTPAPT	DEG_SCF_FBW7_1	0.1111
p.S203G	DO51778	STAD	ICGC	PGTPAPT	DEG_SCF_FBW7_1	0.1111
p.R209I	DO233156	GACA	ICGC	PGTPAPT	DEG_SCF_FBW7_1	0.2778
p.S220R	DO228952	LICA	ICGC	PGTPAPT	DEG_SCF_FBW7_1	0.25
p.A215V	DO222708	MELA	ICGC	PGTPAPT	DEG_SCF_FBW7_1	0.5825
p.I226T	SIDM00545	Melanoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	0.0833
p.I226T	ACH-000987	Skin Cancer	CCLE	PGTPAPT	DEG_SCF_FBW7_1	0.0833
p.I226T	Mewo	skin	COSMIC	PGTPAPT	DEG_SCF_FBW7_1	0.0833
p.I226V	SIDM00773	Non-Cancerous	GDSC	PGTPAPT	DEG_SCF_FBW7_1	0.0833
p.I226V	SIDM01090	Colorectal Carcinoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	0.0833
p.I226V	SIDM00210	Ovarian Carcinoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	0.0833
p.I226V	SIDM00529	Breast Carcinoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	0.0833
p.I226V	SIDM00971	Breast Carcinoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	0.0833
p.I226V	SIDM00493	Other Solid Cancers	GDSC	PGTPAPT	DEG_SCF_FBW7_1	0.0833
p.I226V	SIDM00875	Breast Carcinoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	0.0833
p.I226V	SIDM00309	Mesothelioma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	0.0833
p.I226V	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	0.0833
p.I226V	SIDM00774	Breast Carcinoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	0.0833
p.I226V	SIDM00257	Neuroblastoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	0.0833
p.I226V	SIDM00760	Small Cell Lung Carcinoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	0.0833
p.S220N	SIDM00487	Colorectal Carcinoma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	0.25
p.S220N	ACH-000963	Colon/Colorectal Cancer	CCLE	PGTPAPT	DEG_SCF_FBW7_1	0.25
p.S220N	CCK-81	large_intestine	COSMIC	PGTPAPT	DEG_SCF_FBW7_1	0.25
p.R207I	SIDM01662	Plasma Cell Myeloma	GDSC	PGTPAPT	DEG_SCF_FBW7_1	0.2222
p.R207I	ACH-000564	Myeloma	CCLE	PGTPAPT	DEG_SCF_FBW7_1	0.2222
p.S213G	22RV1	prostate	COSMIC	PGTPAPT	DEG_SCF_FBW7_1	0.6993
p.G212S	NCCIT	testis	COSMIC	PGTPAPT	DEG_SCF_FBW7_1	0.5882

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTPAPT

Degron related mutations and impact score

Drug responses associated with CHRDL2 mutations

All proteins holding degron of PGTPAPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6WN34	Chordin-like protein 2	DEG_SCF_FBW7_1	211:217	PGTPAPT	FBXW7	0.8325	More...