DegronMD

Uniprot ID: P52951

Source protein: Homeobox protein GBX-2

Source gene: GBX2

Class: DEG_SPOP_SBC_1

Location: 238:242

E3 ligase: SPOP

DEGRON score: 0.9792

ASA_SCORE: 77.18

COIL: 0.941

CONS_SCORE: 0.5335

DSS_SCORE: 0.7916

HELIX: 0.0426

FCONS_SCORE: 0.8701

RIG_SCORE: 0.531

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R250W	TCGA-XK-AAIW	PRAD	TCGA	AGSTT	DEG_SPOP_SBC_1	0.1111
p.R250W	DO51407	PRAD	ICGC	AGSTT	DEG_SPOP_SBC_1	0.1111
p.R250W	ACH-001610	Brain Cancer	CCLE	AGSTT	DEG_SPOP_SBC_1	0.1111
p.R251Q	DO48374	BLCA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.0833
p.R249W	DO233624	GACA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.1389
p.R249Q	DO227835	PBCA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.1389
p.A237T	SIDM00111	Glioma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.3056
p.A237T	SIDM00527	Colorectal Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.3056
p.A237T	U251	central_nervous_system	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.3056
p.A237T	MDST8	large_intestine	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.3056
p.R251G	SIDM00196	Ewing's Sarcoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.0833
p.R251G	ACH-002116	Bone Cancer	CCLE	AGSTT	DEG_SPOP_SBC_1	0.0833
p.R251G	EW-22	bone	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52951	Homeobox protein GBX-2	DEG_SPOP_SBC_1	238:242	AGSTT	SPOP	0.9792	More...
Q6WN34	Chordin-like protein 2	DEG_SPOP_SBC_1	235:239	AGSTT	SPOP	0.9287	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	491:495	AGSTT	SPOP	0.9844	More...
Q9BQF6	Sentrin-specific protease 7	DEG_SPOP_SBC_1	387:391	AGSTT	SPOP	0.9925	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1480:1484	AGSTT	SPOP	0.9785	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	765:769	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1820:1824	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3377:3381	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4460:4464	AGSTT	SPOP	0.9616	More...
Q9UPV0	Centrosomal protein of 164 kDa	DEG_SPOP_SBC_1	1404:1408	AGSTT	SPOP	0.8025	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons