DegronMD - P52951(GBX2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G225V	TCGA-BR-8487	STAD	TCGA	LEETPPSS	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.25
p.G225V	DO47867	STAD	ICGC	LEETPPSS	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.25
p.D223G	TCGA-KL-8333	KICH	TCGA	LEETPPSS	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.1944
p.D223G	DO220341	KICH	ICGC	LEETPPSS	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.1944
p.R250W	TCGA-XK-AAIW	PRAD	TCGA	AGSTT	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1111
p.R250W	DO51407	PRAD	ICGC	AGSTT	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1111
p.R250W	ACH-001610	Brain Cancer	CCLE	AGSTT	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1111
p.R251Q	DO48374	BLCA	ICGC	AGSTT	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.0833
p.P233R	DO223538	CLLE	ICGC	LEETPPSS	DEG_SCF_FBW7_1	228:235	Mutation altering degron motif	0.6401
p.A227V	DO234187	ESAD	ICGC	LEETPPSS	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.3056
p.A227V	SIDM01619	Endometrial Carcinoma	GDSC	LEETPPSS	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.3056
p.A227V	ACH-000984	Endometrial/Uterine Cancer	CCLE	LEETPPSS	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.3056
p.R249W	DO233624	GACA	ICGC	AGSTT	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1389
p.P232L	DO222638	MELA	ICGC	LEETPPSS	DEG_SCF_FBW7_1	228:235	Mutation altering degron motif	0.7582
p.R249Q	DO227835	PBCA	ICGC	AGSTT	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1389
p.A237T	SIDM00111	Glioma	GDSC	LEETPPSS	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.2778
p.A237T	SIDM00111	Glioma	GDSC	AGSTT	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.3056
p.A237T	SIDM00527	Colorectal Carcinoma	GDSC	LEETPPSS	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.2778
p.A237T	SIDM00527	Colorectal Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.3056
p.A237T	U251	central nervous system	COSMIC	LEETPPSS	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.2778
p.A237T	U251	central nervous system	COSMIC	AGSTT	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.3056
p.A237T	MDST8	large intestine	COSMIC	LEETPPSS	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.2778
p.A237T	MDST8	large intestine	COSMIC	AGSTT	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.3056
p.R251G	SIDM00196	Ewing's Sarcoma	GDSC	AGSTT	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.0833
p.R251G	ACH-002116	Bone Cancer	CCLE	AGSTT	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.0833
p.R251G	EW-22	bone	COSMIC	AGSTT	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.0833
p.P224L	SIDM01086	B-Lymphoblastic Leukemia	GDSC	LEETPPSS	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.2222
p.P224L	ACH-000874	Leukemia	CCLE	LEETPPSS	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.2222
p.P224L	RS4-11	haematopoietic and lymphoid tissue	COSMIC	LEETPPSS	DEG_SCF_FBW7_1	228:235	Mutation rewiring degron network	0.2222

Kaplan plot for GBX2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GBX2

UniProt ID: P52951

Entrez ID: 2637

Protein name: Homeobox protein GBX-2 (Gastrulation and brain-specific homeobox protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GBX2 in