DegronMD

Uniprot ID: P52951

Source protein: Homeobox protein GBX-2

Source gene: GBX2

Class: DEG_SCF_FBW7_1

Location: 228:235

E3 ligase: FBXW7

DEGRON score: 0.5464

ASA_SCORE: 102.7625

COIL: 0.8969

CONS_SCORE: 0.4703

DSS_SCORE: 0.8322

HELIX: 0.0864

FCONS_SCORE: 0.8865

RIG_SCORE: 0.5771

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G225V	TCGA-BR-8487	STAD	TCGA	LEETPPSS	DEG_SCF_FBW7_1	0.25
p.G225V	DO47867	STAD	ICGC	LEETPPSS	DEG_SCF_FBW7_1	0.25
p.D223G	TCGA-KL-8333	KICH	TCGA	LEETPPSS	DEG_SCF_FBW7_1	0.1944
p.D223G	DO220341	KICH	ICGC	LEETPPSS	DEG_SCF_FBW7_1	0.1944
p.P233R	DO223538	CLLE	ICGC	LEETPPSS	DEG_SCF_FBW7_1	0.6401
p.A227V	DO234187	ESAD	ICGC	LEETPPSS	DEG_SCF_FBW7_1	0.3056
p.A227V	SIDM01619	Endometrial Carcinoma	GDSC	LEETPPSS	DEG_SCF_FBW7_1	0.3056
p.A227V	ACH-000984	Endometrial/Uterine Cancer	CCLE	LEETPPSS	DEG_SCF_FBW7_1	0.3056
p.P232L	DO222638	MELA	ICGC	LEETPPSS	DEG_SCF_FBW7_1	0.7582
p.A237T	SIDM00111	Glioma	GDSC	LEETPPSS	DEG_SCF_FBW7_1	0.2778
p.A237T	SIDM00527	Colorectal Carcinoma	GDSC	LEETPPSS	DEG_SCF_FBW7_1	0.2778
p.A237T	U251	central_nervous_system	COSMIC	LEETPPSS	DEG_SCF_FBW7_1	0.2778
p.A237T	MDST8	large_intestine	COSMIC	LEETPPSS	DEG_SCF_FBW7_1	0.2778
p.P224L	SIDM01086	B-Lymphoblastic Leukemia	GDSC	LEETPPSS	DEG_SCF_FBW7_1	0.2222
p.P224L	ACH-000874	Leukemia	CCLE	LEETPPSS	DEG_SCF_FBW7_1	0.2222
p.P224L	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	LEETPPSS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52951	Homeobox protein GBX-2	DEG_SCF_FBW7_1	228:235	LEETPPSS	FBXW7	0.5464	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons