DegronMD

Uniprot ID: Q9UKN1

Source protein: Mucin-12

Source gene: MUC12

Class: DEG_SPOP_SBC_1

Location: 765:769

E3 ligase: SPOP

DEGRON score: 0.9616

ASA_SCORE: 73.2

COIL: 0.843

CONS_SCORE: 0

DSS_SCORE: 0.743

HELIX: 0.0208

FCONS_SCORE: 0

RIG_SCORE: 0.5674

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T760K	DO225390	BRCA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.1944
p.R770H	DO223058	ESCA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.3056
p.R770H	DO51527	PACA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.3056
p.R770H	COR-L95	lung	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.3056
p.R770C	DO233650	GACA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.3056
p.R770C	DO52692	MALY	ICGC	AGSTT	DEG_SPOP_SBC_1	0.3056
p.G772R	DO220877	MELA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.25
p.S757L	DO220877	MELA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.1111
p.S757L	DO47268	SKCM	ICGC	AGSTT	DEG_SPOP_SBC_1	0.1111
p.S757L	NCI-H835	lung	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1111
p.A765D	DO35550	PBCA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.7793
p.S767P	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.6752
p.S767P	SK-MES-1	lung	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.6752
p.T759R	SIDM01120	Other Solid Cancers	GDSC	AGSTT	DEG_SPOP_SBC_1	0.1667
p.T759R	SK-MEL-2	skin	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1667
p.A776T	SIDM01060	Melanoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.1389
p.A776T	SIDM00519	Mesothelioma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.1389
p.A776T	SIDM00100	Mesothelioma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.1389
p.A776T	H2869	pleura	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1389
p.A776T	H2595	pleura	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1389
p.A776T	LN-18	central_nervous_system	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1389
p.A776T	IGR-1	skin	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1389
p.R770S	ACH-000901	Lung Cancer	CCLE	AGSTT	DEG_SPOP_SBC_1	0.3056
p.A765T	ACH-000941	Endometrial/Uterine Cancer	CCLE	AGSTT	DEG_SPOP_SBC_1	0.7139
p.A765T	ACH-000954	Endometrial/Uterine Cancer	CCLE	AGSTT	DEG_SPOP_SBC_1	0.7139
p.A765T	ACH-001526	Bone Cancer	CCLE	AGSTT	DEG_SPOP_SBC_1	0.7139
p.A765T	YAPC	pancreas	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.7139
p.A765T	HuO9	bone	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.7139
p.H759Y	ACH-001970	Metastasis	CCLE	AGSTT	DEG_SPOP_SBC_1	0.1667
p.T777M	SJSA-1	bone	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1111
p.T776R	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AGSTT

Degron related mutations and impact score

Drug responses associated with MUC12 mutations

All proteins holding degron of AGSTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52951	Homeobox protein GBX-2	DEG_SPOP_SBC_1	238:242	AGSTT	SPOP	0.9792	More...
Q6WN34	Chordin-like protein 2	DEG_SPOP_SBC_1	235:239	AGSTT	SPOP	0.9287	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	491:495	AGSTT	SPOP	0.9844	More...
Q9BQF6	Sentrin-specific protease 7	DEG_SPOP_SBC_1	387:391	AGSTT	SPOP	0.9925	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1480:1484	AGSTT	SPOP	0.9785	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	765:769	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1820:1824	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3377:3381	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4460:4464	AGSTT	SPOP	0.9616	More...
Q9UPV0	Centrosomal protein of 164 kDa	DEG_SPOP_SBC_1	1404:1408	AGSTT	SPOP	0.8025	More...