DegronMD

Uniprot ID: Q9UPV0

Source protein: Centrosomal protein of 164 kDa

Source gene: CEP164

Class: DEG_SPOP_SBC_1

Location: 1404:1408

E3 ligase: SPOP

DEGRON score: 0.8025

ASA_SCORE: 64

COIL: 0.8824

CONS_SCORE: 0.7071

DSS_SCORE: 0.5098

HELIX: 0.0922

FCONS_SCORE: 0.9672

RIG_SCORE: 0.6789

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1417W	TCGA-A5-A0GI	UCEC	TCGA	AGSTT	DEG_SPOP_SBC_1	0.0833
p.R1417W	DO41807	UCEC	ICGC	AGSTT	DEG_SPOP_SBC_1	0.0833
p.A1404T	DO229177	LMS	ICGC	AGSTT	DEG_SPOP_SBC_1	0.7139
p.S1399L	DO222837	MELA	ICGC	AGSTT	DEG_SPOP_SBC_1	0.1944
p.S1399L	SIDM00059	Ovarian Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.1944
p.R1417P	SIDM00455	Pancreatic Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.0833
p.R1417P	ACH-000599	Pancreatic Cancer	CCLE	AGSTT	DEG_SPOP_SBC_1	0.0833
p.R1417P	PA-TU-8902	pancreas	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.0833
p.R1417Q	SIDM00267	Biliary Tract Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.0833
p.R1417Q	ACH-000167	Myeloma	CCLE	AGSTT	DEG_SPOP_SBC_1	0.0833
p.R1417Q	ACH-002312	Gallbladder Cancer	CCLE	AGSTT	DEG_SPOP_SBC_1	0.0833
p.R1417Q	TGBC24TKB	biliary_tract	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.0833
p.Q1400R	SIDM00346	Chronic Myelogenous Leukemia	GDSC	AGSTT	DEG_SPOP_SBC_1	0.2222
p.Q1400R	ACH-000301	Leukemia	CCLE	AGSTT	DEG_SPOP_SBC_1	0.2222
p.Q1400R	LAMA-84	haematopoietic_and_lymphoid_tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.2222
p.Q1400K	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	0.2222
p.Q1400K	H513	pleura	COSMIC	AGSTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52951	Homeobox protein GBX-2	DEG_SPOP_SBC_1	238:242	AGSTT	SPOP	0.9792	More...
Q6WN34	Chordin-like protein 2	DEG_SPOP_SBC_1	235:239	AGSTT	SPOP	0.9287	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	491:495	AGSTT	SPOP	0.9844	More...
Q9BQF6	Sentrin-specific protease 7	DEG_SPOP_SBC_1	387:391	AGSTT	SPOP	0.9925	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1480:1484	AGSTT	SPOP	0.9785	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	765:769	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1820:1824	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3377:3381	AGSTT	SPOP	0.9616	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4460:4464	AGSTT	SPOP	0.9616	More...
Q9UPV0	Centrosomal protein of 164 kDa	DEG_SPOP_SBC_1	1404:1408	AGSTT	SPOP	0.8025	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons