DegronMD

Uniprot ID: Q9H4A3

Source protein: Serine/threonine-protein kinase WNK1

Source gene: WNK1

Class: DEG_SCF_FBW7_1

Location: 845:852

E3 ligase: FBXW7

DEGRON score: 0.9898

ASA_SCORE: 81.025

COIL: 0.887

CONS_SCORE: 0.349

DSS_SCORE: 0.3842

HELIX: 0.022

FCONS_SCORE: 0.9918

RIG_SCORE: 0.715

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H850R	TCGA-18-3411	LUSC	TCGA	PISTPHVS	DEG_SCF_FBW7_1	0.7133
p.Q838E	TCGA-4Z-AA7M	BLCA	TCGA	PISTPHVS	DEG_SCF_FBW7_1	0.1389
p.T856A	TCGA-AJ-A3EL	UCEC	TCGA	PISTPHVS	DEG_SCF_FBW7_1	0.2222
p.P840T	TCGA-D3-A2JB	SKCM	TCGA	PISTPHVS	DEG_SCF_FBW7_1	0.1944
p.P857S	DO219647	BRCA	ICGC	PISTPHVS	DEG_SCF_FBW7_1	0.1944
p.V843F	DO229031	LICA	ICGC	PISTPHVS	DEG_SCF_FBW7_1	0.2778
p.R850L	DO229036	LICA	ICGC	PISTPHVS	DEG_SCF_FBW7_1	0.8428
p.S846F	DO26918	LUSC	ICGC	PISTPHVS	DEG_SCF_FBW7_1	0.7982
p.E858K	DO26469	LUSC	ICGC	PISTPHVS	DEG_SCF_FBW7_1	0.1667
p.P836S	DO220877	MELA	ICGC	PISTPHVS	DEG_SCF_FBW7_1	0.0833
p.R860L	DO47903	STAD	ICGC	PISTPHVS	DEG_SCF_FBW7_1	0.1111
p.S839Y	DO42129	UCEC	ICGC	PISTPHVS	DEG_SCF_FBW7_1	0.1667
p.A847V	DO41536	UCEC	ICGC	PISTPHVS	DEG_SCF_FBW7_1	0.6936
p.H856R	SIDM00845	Burkitt's Lymphoma	GDSC	PISTPHVS	DEG_SCF_FBW7_1	0.2222
p.H856R	SIDM00461	Acute Myeloid Leukemia	GDSC	PISTPHVS	DEG_SCF_FBW7_1	0.2222
p.H856R	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PISTPHVS	DEG_SCF_FBW7_1	0.2222
p.H856R	SIDM01519	Head and Neck Carcinoma	GDSC	PISTPHVS	DEG_SCF_FBW7_1	0.2222
p.H856R	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PISTPHVS	DEG_SCF_FBW7_1	0.2222
p.H856R	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PISTPHVS	DEG_SCF_FBW7_1	0.2222
p.P840H	SIDM00660	Colorectal Carcinoma	GDSC	PISTPHVS	DEG_SCF_FBW7_1	0.1944
p.P840H	ACH-000985	Colon/Colorectal Cancer	CCLE	PISTPHVS	DEG_SCF_FBW7_1	0.1944
p.P840H	LS-411N	large_intestine	COSMIC	PISTPHVS	DEG_SCF_FBW7_1	0.1944
p.R845C	SIDM00051	Chondrosarcoma	GDSC	PISTPHVS	DEG_SCF_FBW7_1	0.8301
p.R845C	CHSA0011	bone	COSMIC	PISTPHVS	DEG_SCF_FBW7_1	0.8301
p.I841V	SIDM00238	Ovarian Carcinoma	GDSC	PISTPHVS	DEG_SCF_FBW7_1	0.2222
p.I841V	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	PISTPHVS	DEG_SCF_FBW7_1	0.2222
p.I841V	OVK-18	ovary	COSMIC	PISTPHVS	DEG_SCF_FBW7_1	0.2222
p.Q855P	SIDM00948	Burkitt's Lymphoma	GDSC	PISTPHVS	DEG_SCF_FBW7_1	0.25
p.Q855P	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	PISTPHVS	DEG_SCF_FBW7_1	0.25
p.I841F	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	PISTPHVS	DEG_SCF_FBW7_1	0.2222
p.I841F	NCI-H1435	lung	COSMIC	PISTPHVS	DEG_SCF_FBW7_1	0.2222
p.Q838R	SIDM00901	Endometrial Carcinoma	GDSC	PISTPHVS	DEG_SCF_FBW7_1	0.1389
p.Q838R	ACH-000940	Endometrial/Uterine Cancer	CCLE	PISTPHVS	DEG_SCF_FBW7_1	0.1389
p.Q838R	AN3-CA	endometrium	COSMIC	PISTPHVS	DEG_SCF_FBW7_1	0.1389
p.G854E	REH	haematopoietic_and_lymphoid_tissue	COSMIC	PISTPHVS	DEG_SCF_FBW7_1	0.2778
p.V839A	LS-180	large_intestine	COSMIC	PISTPHVS	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PISTPHVS

Degron related mutations and impact score

Drug responses associated with WNK1 mutations

All proteins holding degron of PISTPHVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SCF_FBW7_1	845:852	PISTPHVS	FBXW7	0.9898	More...