DegronMD

Uniprot ID: Q9H4A3

Source protein: Serine/threonine-protein kinase WNK1

Source gene: WNK1

Class: DEG_APCC_DBOX_1

Location: 1116:1124

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8594

ASA_SCORE: 85.5333

COIL: 0.4292

CONS_SCORE: 0.4028

DSS_SCORE: 0.6037

HELIX: 0.0107

FCONS_SCORE: 1.0437

RIG_SCORE: 0.7307

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1109L	TCGA-52-7809	LUSC	TCGA	SRPKLRILN	DEG_APCC_DBOX_1	0.1389
p.R1109H	TCGA-AP-A1DV	UCEC	TCGA	SRPKLRILN	DEG_APCC_DBOX_1	0.1389
p.R1111Q	TCGA-EO-A22R	UCEC	TCGA	SRPKLRILN	DEG_APCC_DBOX_1	0.1944
p.H1127D	DO51914	BLCA	ICGC	SRPKLRILN	DEG_APCC_DBOX_1	0.25
p.K1124N	DO219087	BLCA	ICGC	SRPKLRILN	DEG_APCC_DBOX_1	0.6918
p.P1109H	DO222874	COCA	ICGC	SRPKLRILN	DEG_APCC_DBOX_1	0.1389
p.G1132A	DO14284	HNSC	ICGC	SRPKLRILN	DEG_APCC_DBOX_1	0.1111
p.S1107C	DO27945	ORCA	ICGC	SRPKLRILN	DEG_APCC_DBOX_1	0.0833
p.L1122V	DO51309	PRAD	ICGC	SRPKLRILN	DEG_APCC_DBOX_1	0.6765
p.A1119T	DO223286	UCEC	ICGC	SRPKLRILN	DEG_APCC_DBOX_1	0.7139
p.A1119T	DO42673	UCEC	ICGC	SRPKLRILN	DEG_APCC_DBOX_1	0.7139
p.V1116A	DO43041	UCEC	ICGC	SRPKLRILN	DEG_APCC_DBOX_1	0.6936
p.V1115M	DO52399	UCEC	ICGC	SRPKLRILN	DEG_APCC_DBOX_1	0.75
p.V1120L	SIDM00281	Other Solid Cancers	GDSC	SRPKLRILN	DEG_APCC_DBOX_1	0.6765
p.V1120L	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	SRPKLRILN	DEG_APCC_DBOX_1	0.6765
p.V1120L	SIDM00603	Head and Neck Carcinoma	GDSC	SRPKLRILN	DEG_APCC_DBOX_1	0.6765
p.V1120L	SIDM00164	Biliary Tract Carcinoma	GDSC	SRPKLRILN	DEG_APCC_DBOX_1	0.6765
p.K1107R	SIDM00537	Colorectal Carcinoma	GDSC	SRPKLRILN	DEG_APCC_DBOX_1	0.0833
p.K1107R	GP5d	large_intestine	COSMIC	SRPKLRILN	DEG_APCC_DBOX_1	0.0833
p.R1117C	ACH-000966	Ovarian Cancer	CCLE	SRPKLRILN	DEG_APCC_DBOX_1	0.8301
p.H1112Y	ACH-000980	Lung Cancer	CCLE	SRPKLRILN	DEG_APCC_DBOX_1	0.2222
p.H1112Y	NCI-H1155	lung	COSMIC	SRPKLRILN	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_APCC_DBOX_1	1116:1124	SRPKLRILN	APC,CDC20,FZR1	0.8594	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons