DegronMD

Uniprot ID: Q9H4A3

Source protein: Serine/threonine-protein kinase WNK1

Source gene: WNK1

Class: DEG_SPOP_SBC_1

Location: 2237:2241

E3 ligase: SPOP

DEGRON score: 0.9939

ASA_SCORE: 79.18

COIL: 0.8332

CONS_SCORE: 0.3801

DSS_SCORE: 0.6234

HELIX: 0.14

FCONS_SCORE: 0.9608

RIG_SCORE: 0.6675

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2239M	TCGA-QF-A5YS	UCEC	TCGA	AMTSS	DEG_SPOP_SBC_1	0.7423
p.A2237P	TCGA-DX-AB2Q	SARC	TCGA	AMTSS	DEG_SPOP_SBC_1	0.6392
p.H2251P	TCGA-5P-A9K2	KIRP	TCGA	AMTSS	DEG_SPOP_SBC_1	0.0556
p.N2227S	ACH-000986	Colon/Colorectal Cancer	CCLE	AMTSS	DEG_SPOP_SBC_1	0.0556
p.N2227S	HT-115	large_intestine	COSMIC	AMTSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 5 of 5 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SPOP_SBC_1	185:189	AMTSS	SPOP	0.9295	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	2237:2241	AMTSS	SPOP	0.9939	More...

Showing 1 to 2 of 2 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons